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GPCR

NameG-protein coupled receptor 182
SpeciesHomo sapiens (Human)
GeneGPR182
SynonymNOW
L1-R
GPR182
Gpcr22
Gpcr17
[ Show all ]
DiseaseN/A
Length404
Amino acid sequenceMSVKPSWGPGPSEGVTAVPTSDLGEIHNWTELLDLFNHTLSECHVELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGIVLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASPSWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVEGPEPMCLFMAPFETYSTWALAVALSTTILGFLLPFPLITVFNVLTACRLRQPGQPKSRRHCLLLCAYVAVFVMCWLPYHVTLLLLTLHGTHISLHCHLVHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNAVVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPS
UniProtO15218
Protein Data BankN/A
GPCR-HGmod modelO15218
3D structure modelThis predicted structure model is from GPCR-EXP O15218.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4356
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL361867
Molecular formulaC36H36N6O2
IUPAC name4-benzyl-3-[4-[4-benzyl-5-(phenoxymethyl)-1,2,4-triazol-3-yl]butyl]-5-(phenoxymethyl)-1,2,4-triazole
Molecular weight584.724
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP6.1
SynonymsN/A
Inchi KeyYSGVAQGHIYGWLA-UHFFFAOYSA-N
Inchi IDInChI=1S/C36H36N6O2/c1-5-15-29(16-6-1)25-41-33(37-39-35(41)27-43-31-19-9-3-10-20-31)23-13-14-24-34-38-40-36(28-44-32-21-11-4-12-22-32)42(34)26-30-17-7-2-8-18-30/h1-12,15-22H,13-14,23-28H2
PubChem CID11204057
ChEMBLCHEMBL361867
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Affinity19.0 %PMID15943480ChEMBL

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