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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Lysophosphatidic acid receptor 4
Species	Homo sapiens (Human)
Gene	LPAR4
Synonym	Purinergic receptor 9 P2Y9 P2Y5-like receptor P2Y purinoceptor 9 P2RY9 G-protein coupled receptor 23 G protein-coupled receptor 23 LPA4 LPA-4 LPA receptor 4 GPR23 LPA4 receptor [ Show all ]
Disease	N/A
Length	370
Amino acid sequence	MGDRRFIDFQFQDSNSSLRPRLGNATANNTCIVDDSFKYNLNGAVYSVVFILGLITNSVSLFVFCFRMKMRSETAIFITNLAVSDLLFVCTLPFKIFYNFNRHWPFGDTLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVNNATTTCFEGFSKRVWKTYLSKITIFIEVVGFIIPLILNVSCSSVVLRTLRKPATLSQIGTNKKKVLKMITVHMAVFVVCFVPYNSVLFLYALVRSQAITNCFLERFAKIMYPITLCLATLNCCFDPFIYYFTLESFQKSFYINAHIRMESLFKTETPLTTKPSLPAIQEEVSDQTTNNGGELMLESTF
UniProt	Q99677
Protein Data Bank	N/A
GPCR-HGmod model	Q99677
3D structure model	This predicted structure model is from GPCR-EXP Q99677.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5968
IUPHAR	94
DrugBank	N/A

Ligand

Name	1-Hexadecanoyl-sn-glycero-3-phosphate
Molecular formula	C19H39O7P
IUPAC name	[(2R)-2-hydroxy-3-phosphonooxypropyl] hexadecanoate
Molecular weight	410.488
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	5.0
Synonyms	Lysophosphatidic acid(16:0) [(2R)-2-hydroxy-3-phosphonooxypropyl] hexadecanoate 1-palmitoyl-sn-glycerol 3-phosphate Hexadecanoic acid, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester PA(16:0/0:0) LPA(16:0/0:0) SCHEMBL2935665 (2R)-2-hydroxy-3-(phosphonooxy)propyl palmitate BDBM50430013 Lysophosphatidic acid(16:0/0:0) 1-palmitoyl-sn-glycerol-3-phosphate CHEMBL364797 Hexadecanoic acid, 2-hydroxy-3-(phosphonooxy)propyl ester, (R)- Palmitin, 1-mono-, 3-(dihydrogen phosphate), L- 7220-34-0 LysoPA(16:0/0:0) ZINC8219000 CHEBI:15799 NKO 1-Palmitoyl-sn-glyceryl 3-phosphate CTK2H2733 LMGP10050006 Palmitoyl lysophosphatidic acid (2R)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate AC1O4WBH [ Show all ]
Inchi Key	YNDYKPRNFWPPFU-GOSISDBHSA-N
Inchi ID	InChI=1S/C19H39O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(21)25-16-18(20)17-26-27(22,23)24/h18,20H,2-17H2,1H3,(H2,22,23,24)/t18-/m1/s1
PubChem CID	6419701
ChEMBL	CHEMBL364797
IUPHAR	N/A
BindingDB	50430013
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	83.18 nM	PMID23395664	ChEMBL
EC50	84.0 nM	PMID23395664	BindingDB,ChEMBL
Intrinsic activity	0.14 -	PMID23395664	ChEMBL

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