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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lysophosphatidic acid receptor 1
Species	Homo sapiens (Human)
Gene	LPAR1
Synonym	lysophosphatidic acid receptor Edg-2 Lpar1 LPA1 receptor Lysophosphatidic acid receptor Edg-2 {ECO:0000303\|PubMed:9070858} LPA-1 LPA receptor 1 GPR26 endothelial differentiation gene 2, lysophosphatidic acid G-protein-coupled receptor, 2 EDG2 VZG1 [ Show all ]
Disease	Idiopathic pulmonary fibrosis
Length	364
Amino acid sequence	MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProt	Q92633
Protein Data Bank	4z36, 4z35, 4z34
GPCR-HGmod model	Q92633
3D structure model	This structure is from PDB ID 4z36.
BioLiP	BL0315557, BL0315553, BL0315554, BL0315555, BL0315556, BL0315558
Therapeutic Target Database	T92640
ChEMBL	CHEMBL3819
IUPHAR	272
DrugBank	N/A

Ligand

Name	1-Hexadecanoyl-sn-glycero-3-phosphate
Molecular formula	C19H39O7P
IUPAC name	[(2R)-2-hydroxy-3-phosphonooxypropyl] hexadecanoate
Molecular weight	410.488
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	5.0
Synonyms	1-palmitoyl-sn-glycerol 3-phosphate Lysophosphatidic acid(16:0) [(2R)-2-hydroxy-3-phosphonooxypropyl] hexadecanoate Hexadecanoic acid, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester PA(16:0/0:0) (2R)-2-hydroxy-3-(phosphonooxy)propyl palmitate BDBM50430013 LPA(16:0/0:0) SCHEMBL2935665 1-palmitoyl-sn-glycerol-3-phosphate CHEMBL364797 Lysophosphatidic acid(16:0/0:0) 7220-34-0 Hexadecanoic acid, 2-hydroxy-3-(phosphonooxy)propyl ester, (R)- Palmitin, 1-mono-, 3-(dihydrogen phosphate), L- CHEBI:15799 LysoPA(16:0/0:0) ZINC8219000 1-Palmitoyl-sn-glyceryl 3-phosphate CTK2H2733 NKO (2R)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate AC1O4WBH LMGP10050006 Palmitoyl lysophosphatidic acid [ Show all ]
Inchi Key	YNDYKPRNFWPPFU-GOSISDBHSA-N
Inchi ID	InChI=1S/C19H39O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(21)25-16-18(20)17-26-27(22,23)24/h18,20H,2-17H2,1H3,(H2,22,23,24)/t18-/m1/s1
PubChem CID	6419701
ChEMBL	CHEMBL364797
IUPHAR	N/A
BindingDB	50430013
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	70.79 nM	PMID23395664	ChEMBL
EC50	71.0 nM	PMID23395664	BindingDB,ChEMBL
Intrinsic activity	0.24 -	PMID23395664	ChEMBL

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