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GPCR

NameG-protein coupled receptor 35
SpeciesHomo sapiens (Human)
GeneGPR35
SynonymG-protein coupled receptor 3
GPR35
KYNA receptor
Kynurenic acid receptor
DiseaseN/A
Length309
Amino acid sequenceMNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProtQ9HC97
Protein Data BankN/A
GPCR-HGmod modelQ9HC97
3D structure modelThis predicted structure model is from GPCR-EXP Q9HC97.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293267
IUPHAR102
DrugBankBE0005562

Ligand

NameCHEMBL2392167
Molecular formulaC18H12ClNO6
IUPAC name6-chloro-8-[(4-methoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid
Molecular weight373.745
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP2.7
SynonymsBDBM50436007
Inchi KeyYMINVJCQMHQVBJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H12ClNO6/c1-25-11-4-2-9(3-5-11)17(22)20-13-7-10(19)6-12-14(21)8-15(18(23)24)26-16(12)13/h2-8H,1H3,(H,20,22)(H,23,24)
PubChem CID71733744
ChEMBLCHEMBL2392167
IUPHARN/A
BindingDB50436007
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5016.8 nMPMID23713606, PMID23888932ChEMBL
EC5016.98 nMPMID23713606ChEMBL
EC5017.0 nMPMID23713606, PMID23888932BindingDB
EC5028.6 nMPMID23713606ChEMBL
EC5029.0 nMPMID23713606BindingDB
Emax110.0 %PMID23713606ChEMBL
Emax125.0 %PMID23713606ChEMBL
Ki5.5 nMPMID23888932BindingDB,ChEMBL

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