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GPCR

NameGlucagon receptor
SpeciesHomo sapiens (Human)
GeneGCGR
SynonymGL-R
GGR
GR
glucagon receptor
DiseaseDiabetes
Type 2 diabetes
Non-insulin dependent diabetes
Obesity; Diabetes
Type 1 diabetes
[ Show all ]
Length477
Amino acid sequenceMPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProtP47871
Protein Data Bank5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod modelP47871
3D structure modelThis structure is from PDB ID 5yqz.
BioLiPBL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target DatabaseT60182, T87875
ChEMBLCHEMBL1985
IUPHAR251
DrugBankN/A

Ligand

NameCHEMBL346694
Molecular formulaC24H19ClF3N3O5S
IUPAC name3-chloro-4-hydroxy-N-[(E)-[2-methoxy-4-[[2-[4-(trifluoromethoxy)phenyl]sulfanylacetyl]amino]phenyl]methylideneamino]benzamide
Molecular weight553.937
Hydrogen bond acceptor10
Hydrogen bond donor3
XlogP5.7
SynonymsBDBM50122164
N-{4-[(3-Chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-3-methoxy-phenyl}-2-(4-trifluoromethoxy-phenylsulfanyl)-acetamide
Inchi KeyCFYJQUAXHBEEGM-XKJRVUDJSA-N
Inchi IDInChI=1S/C24H19ClF3N3O5S/c1-35-21-11-16(30-22(33)13-37-18-7-5-17(6-8-18)36-24(26,27)28)4-2-15(21)12-29-31-23(34)14-3-9-20(32)19(25)10-14/h2-12,32H,13H2,1H3,(H,30,33)(H,31,34)/b29-12+
PubChem CID10907780
ChEMBLCHEMBL346694
IUPHARN/A
BindingDB50122164
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5014.5 nMPMID12477359BindingDB,ChEMBL

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