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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Metabotropic glutamate receptor 7
Species	Rattus norvegicus (Rat)
Gene	Grm7
Synonym	GLUR7 glutamate receptor GPRC1G mGlu7 receptor mGlu7a receptor mGluR7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	915
Amino acid sequence	MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
UniProt	P35400
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3879
IUPHAR	295
DrugBank	N/A

Ligand

Name	(1S,3R)-ACPD
Molecular formula	C7H11NO4
IUPAC name	(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid
Molecular weight	173.168
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-3.2
Synonyms	(1S,3S)-1-amino-1,3-cyclopentanedicarboxylic acid trans-(+/-)-ACPD 1-amino-1,3-dicarboxycyclopentane, (cis)-(+-)-isomer ZINC2004213 1-aminocyclopentyl-1,3-dicarboxylic acid 67684-64-4 B6245 cid_16218853 FT-0639514 J-500459 NCGC00024488-05 SR-01000597678 t-ACPD 1,3-Cyclopentanedicarboxylic acid, 1-amino-, (1S,3R)- trans-(?)-ACPD 1-amino-1,3-dicarboxycyclopentane, cis-(1R,3R)-isomer AC1Q5QYM C5b CTK0H3900 GTPL1365 LS-57947 PDSP2_000800 (1S,3R)-1-ACPD trans-( inverted question mark)-1-Amino-1,3-cyclopentanedicarboxylic acid 1-Amino-1,3-cyclopentanedicarboxylic acid trans-ACPD 1-amino-cyclopentyl-trans-1S,3R-dicarboxylate 27-84-9 AKOS017344535 FCH839908 InChI=1/C7H11NO4/c8-7(6(11)12)2-1-4(3-7)5(9)10/h4H,1-3,8H2,(H,9,10)(H,11,12)/t4-,7+/m1/s1 NCGC00024488-03 SR-01000075420 (1S,3R)-1-azanylcyclopentane-1,3-dicarboxylic acid;hydrate (1S,3S)-ACPD trans-(1S,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid 1-amino-1,3-dicarboxycyclopentane, (trans)-(+-)-isomer 111900-32-4 A-155 BDBM66976 cis-1-amino-1,3-cyclopentanecarboxylic acid FT-0695375 Lopac0_000097 NCGC00260782-01 SR-01000597678-1 Tox21_500097 1,3-Cyclopentanedicarboxylic acid, 1-amino-, (1S-cis)- trans-(y)-ACPD 1-amino-1,3-dicarboxycyclopentane, cis-(1S,3S)-isomer 149881-50-5 ACPD CB 1712 D04DKM HMS3260C16 MLS002153209 SCHEMBL179741 (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid trans-( inverted question mark)-ACPD 1-Amino-1,3-dicarboxycyclopentane YFYNOWXBIBKGHB-FBCQKBJTSA- 1-Aminocyclopentane-1S,3R-dicarboxylic acid B6220 CHEMBL34453 FT-0639513 J-500447 NCGC00024488-04 SR-01000075420-1 (trans)-1-aminocyclopentyl-1,3-dicarboxylate trans-(1S,3R)-ACPD 1-amino-1,3-dicarboxycyclopentane, (trans)-isomer 130942-93-7 AC1L2XGH BN0051 cis-ACPD FT-0695378 LP00097 PDSP1_000813 SR-01000597678-2 trans-( )-ACPD monohydrate 1,3-Cyclopentanedicarboxylicacid, 1-amino-, (1S,3R)- trans-1-aminocyclopentane-1,3-dicarboxylate 1-amino-1,3-dicarboxycyclopentane, trans-(1R,3S)-isomer 1S,3R-ACPD ACPD-1S,3R CCG-204192 EU-0100097 I04-8357 MolPort-003-940-060 SMR001230688 (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid;hydrate [ Show all ]
Inchi Key	YFYNOWXBIBKGHB-FBCQKBJTSA-N
Inchi ID	InChI=1S/C7H11NO4/c8-7(6(11)12)2-1-4(3-7)5(9)10/h4H,1-3,8H2,(H,9,10)(H,11,12)/t4-,7+/m1/s1
PubChem CID	104766
ChEMBL	CHEMBL34453
IUPHAR	1365
BindingDB	66976
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<1000000.0 nM	PMID7738999	BindingDB,ChEMBL

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