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GPCR

NameTrace amine-associated receptor 1
SpeciesMus musculus (Mouse)
GeneTaar1
SynonymTA1 receptor
TaR-1
TAR1
trace amine receptor 1
TRAR1
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProtQ923Y8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4908
IUPHAR364
DrugBankN/A

Ligand

NameCHEMBL3701902
Molecular formulaC20H22ClF3N2
IUPAC nameN-[1-(4-chlorophenyl)-2,2,2-trifluoroethyl]-4-(2-pyrrolidin-3-ylethyl)aniline
Molecular weight382.855
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP5.8
SynonymsUS8802673, 3
BDBM129361
SCHEMBL12609679
Inchi KeyCFMRPOMTQYDAMK-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H22ClF3N2/c21-17-7-5-16(6-8-17)19(20(22,23)24)26-18-9-3-14(4-10-18)1-2-15-11-12-25-13-15/h3-10,15,19,25-26H,1-2,11-13H2
PubChem CID68325464
ChEMBLCHEMBL3701902
IUPHARN/A
BindingDB129361
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki15.7 nM, NoneBindingDB,ChEMBL

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