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GPCR

NameG-protein coupled receptor homolog US28
SpeciesHuman cytomegalovirus (strain AD169) (HHV-5)
GeneUS28
SynonymHHRF3
DiseaseN/A for non-human GPCRs
Length354
Amino acid sequenceMTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
UniProtP69332
Protein Data Bank4xt1
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 4xt1.
BioLiPBL0309402,BL0309403
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4259
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL197694
Molecular formulaC29H32N2O
IUPAC name5-[4-hydroxy-4-(4-methylphenyl)piperidin-1-yl]-2,2-diphenylpentanenitrile
Molecular weight424.588
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.4
SynonymsBDBM50027225
SCHEMBL9911005
5-(4-Hydroxy-4-p-tolyl-piperidin-1-yl)-2,2-diphenyl-pentanenitrile
Inchi KeyYBZPTFKPXHZAER-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H32N2O/c1-24-13-15-27(16-14-24)29(32)18-21-31(22-19-29)20-8-17-28(23-30,25-9-4-2-5-10-25)26-11-6-3-7-12-26/h2-7,9-16,32H,8,17-22H2,1H3
PubChem CID11698316
ChEMBLCHEMBL197694
IUPHARN/A
BindingDB50027225
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5060300.0 nMPMID16190772BindingDB,ChEMBL

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