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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	2-oxoglutarate receptor 1
Species	Rattus norvegicus (Rat)
Gene	Oxgr1
Synonym	P2Y purinoceptor 15 P2RY15 oxoglutarate receptor GPR99 GPR80 G-protein coupled receptor 80 G protein-coupled receptor 99 G protein-coupled receptor 80 Alpha-ketoglutarate receptor 1 2-oxoglutarate receptor 1 P2Y15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	337
Amino acid sequence	MIETLDSPANDSDFLDYITALENCTDEQISFKMQYLPVIYSIIFLVGFPGNTVAISIYVFKMRPWKSSTIIMLNLALTDLLYLTSLPFLIHYYASGENWIFGDFMCKFIRFGFHFNLYSSILFLTCFSLFRYIVIIHPMSCFSIQKTRWAVVACAGVWVISLVAVMPMTFLITSTTRTNRSACLDLTSSDDLTTIKWYNLILTATTFCLPLLIVTLCYTTIISTLTHGPRTHSCFKQKARRLTILLLLVFYVCFLPFHILRVIRIESRLLSISCSIESHIHEAYIVSRPLAALNTFGNLLLYVVVSNNFQQAFCSAVRCKAIGDLEQAKKDSCSNNP
UniProt	Q6Y1R5
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2325
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL129903
Molecular formula	C12H17N7O4
IUPAC name	(2S,3S,4R,5R)-N-(2-aminoethyl)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamide
Molecular weight	323.313
Hydrogen bond acceptor	9
Hydrogen bond donor	5
XlogP	-2.0
Synonyms	5'-N-[(2-Amino)ethyl Carboxamido] Adenosine Adenosine analog, 1 5''-N-[(2-AMINO)ETHYL CARBOXAMIDO] ADENOSINE 5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid (2-amino-ethyl)-amide (2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-(2-aminoethyl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide BDBM50106539 5'-Deoxy-5'-(2-aminoethyl)amino-5'-oxoadenosine N5A (2S,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid (2-amino-ethyl)-amide [ Show all ]
Inchi Key	XZUQLQNOMFGRFJ-FLNNQWSLSA-N
Inchi ID	InChI=1S/C12H17N7O4/c13-1-2-15-11(22)8-6(20)7(21)12(23-8)19-4-18-5-9(14)16-3-17-10(5)19/h3-4,6-8,12,20-21H,1-2,13H2,(H,15,22)(H2,14,16,17)/t6-,7+,8-,12+/m0/s1
PubChem CID	9996282
ChEMBL	CHEMBL129903
IUPHAR	N/A
BindingDB	50106539
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	167.0 nM	PMID11170630	BindingDB,ChEMBL

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