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GLASS

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GPCR

Name	D(1A) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd1
Synonym	D1 receptor D1A DADR dopamine D1 receptor Dopamine-1A receptor Gpcr15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProt	P18901
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL265
IUPHAR	214
DrugBank	N/A

Ligand

Name	diazepam
Molecular formula	C16H13ClN2O
IUPAC name	7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Molecular weight	284.743
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.0
Synonyms	Tranqdyn 7-chloro-1-methyl-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one D0Y1YC Unisedil 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Dialar Valium R AKOS003367969 Diastat, Valium Vival Ansilive Diazepam (JP17/USP/INN) Zepaxid Apozepam Diazepam Intensol BCP0726000176 SCHEMBL21442 Diazepam, European Pharmacopoeia (EP) Reference Standard Bialzepam Servizepam C06948 Solis 2H-1, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- CC-26451 T-quil 7-chloranyl-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one CHEMBL12 Metamidol Dienpax Mono (2-ethylhexyl) phthalate Doval Nellium Dupin Noan Eurosan NSC169897 Gewacalm Parzam Horizon Plumiaz Kabivitrum Q3JTX2Q7TU LA III Renborin Lovium CPD000058398 Tranquo-puren 7-Chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Desconet Valeo A826456 Diapine Vanconin Alupram Diazem Winii Antenex Diazepam Dak Assival S.A. R.L Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material BDBM50000766 Seduksen Diazepam-Lipuro BRD-K16508793-001-01-8 Sibazone Calmociteno Spectrum4_000576 439-14-5 Centrazepam Tox21_113071 7-chloro-1-methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one Methyldiazepinone (pharmaceutical) Dipezona NCGC00178168-01 DSSTox_GSID_20406 neurolytr il e-Pam Novo-Dipam Faustan Ortopsique GTPL3364 Paxum I06-0194 Pro pam KBioGR_001012 Quievita Lamra Ro-52807 Mandro-Zep Diazepamum [INN-Latin] Tranimul 7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one D00293 Umbrium 7-Chloro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Diaceplex Valium AC-10561 Diastat (TN) Vazepam An-Ding WY-3467 Apaurin Diazepam Fabra Azedipamin SAM001246536 Diazepam [USAN:INN:BAN:JAN] Best [Pharaceutical] Serenamin Diazepamu [Polish] BSPBio_003279 Sipam 1-Methyl-5-phenyl-7-chloro-1,4-benzodiazepin-2-one CAS-439-14-5 Stesolin 53320-84-6 CHEBI:49575 Diazepin MLS000759402 Dizac NCGC00178168-04 Ducene Nivalen Eridan NSC-169897 Frustan Paralium HMS3393N04 Placidox 5 InChI=1/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H Q-pam Kratium 2 Relanium Liberetas Medipam Chuansuan Tranquase 7-Chloro-1-methyl-5-phenyl-1,4-benzodiazepin-2-one DB00829 Usempax ap 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one. Diapam Valrelease Alboral Diatran Vivol Ansiolin Diazepam 0.1 mg/ml in Methanol ZINC6427 Armonil Diazepam Nordic BCP23002 Sedapam Diazepam, United States Pharmacopeia (USP) Reference Standard BIDD:GT0105 Setonil Calmaven Sonacon 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- CCG-100997 Tensium 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H -1,4-benzodiazepin-2-one Methyl diazepinone Dipam Morosan Drenian Nerozen Duxen Notense Evacalm NSC77518 Gihitan Paxate HSDB 3057 Pms-Diazepam KBio1_000967 Quetinil LA-111 Ro 5-2805 LS-122 CS-0653 Tranquo-tablinen 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one Desloneg Valiquid AAOVKJBEBIDNHE-UHFFFAOYSA-N Diaquel Vatran Amiprol Diazemuls WLN: T67 GNV JN IHJ CG G1 KR Anxicalm Diazepam Desitin Atensine S.a. r.l. Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis Bensedin Seduxen Diazepam-ratiopharm Britazepam Sico Relax (Z)-7-chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Calmod Spectrum5_001890 5-24-04-00300 (Beilstein Handbook Reference) Cercine Tox21_113071_1 7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine Diazepan Methyldiazepinone, pharmaceutical Disopam NCGC00178168-02 DSSTox_RID_75566 Neurolytril EINECS 207-122-5 Novodipam Faustan, Paceum Gubex Placidox 10 Iazepam Prozepam Kiatrium Radizepam Lembrol Ruhsitus Mandrozep Trankinon 7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one D07JVL UNII-Q3JTX2Q7TU 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one Dialag Valium (TN) AC1L1EZE Diastat Acudial Velium Anlin Diazepam (intranasal, epilepsy) ZB000640 Apo-diazepam Diazepam for system suitability, European Pharmacopoeia (EP) Reference Standard Baogin Saromet Diazepam [USAN:USP:INN:BAN:JAN] Betapam Serenzin C-17931 SMR000058398 11100-37-1 Caudel STK735517 7 -chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Diazetard MLS001424086 Domalium NCGC00260007-01 Duksen Nixtensyn Euphorin P NSC-77518 FT-0632135 Paranten HMS503A15 Plidan Jinpanfan Q-Pam Relanium LA 111 Reliver Lizan Mentalium Condition Tranquirit 7-chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2(3H)on DEA No. 2765 Valaxona A3662/0155188 Diapax Valuzepam Aliseum Diazapam W-5055 Ansiolisina Diazepam 1.0 mg/ml in Methanol Zipan Arzepam Diazepam Rectubes BCP9000199 Sedipam Diazepam-Eurogenerics BIDD:PXR0158 Sibazon Calmocitene Spectrum3_001780 CCRIS 6009 Tensopam 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Methyldiazepinone Dipaz NC00247 DSSTox_CID_406 Nervium DZP Novazam Faustal Oprea1_126223 Gradual Paxel HY-17027 Pomin KBio3_002780 Quiatril La-Iii Ro 5-2807 Mandro Diazepamum 7-Chloro-1-methyl-5-3H-1,4-benzodiazepin-2(1H)-one D-Pam Trazepam 7-Chloro-1-methyl-5-phenyl-2-oxo-2,3-dihydro-1H-benzo[f]-1,4-diazepine Diacepan Valitran AB02310 Diastat Vazen AN-23449 Diazemulus Wy 3467 Anxionil Diazepam Elmu Atilen S.A.R.L. Diazepam Stada Benzopin Serenack Diazepamu BRN 0754371 Simasedan 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one Calmpose Stesolid Ceregulart Tox21_202458 Diazepan leo Metil Gobanal DivK1c_000967 NCGC00178168-03 DTXSID4020406 NINDS_000967 Elcion CR NSC 169897 Freudal Pacitran HMS2051N04 Placidox 2 IDI1_000967 Psychopax Kratium Relaminal Levium MCULE-8990989144 [ Show all ]
Inchi Key	AAOVKJBEBIDNHE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
PubChem CID	3016
ChEMBL	CHEMBL12
IUPHAR	3364
BindingDB	50000766
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID6387355	BindingDB

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