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GLASS

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GPCR

Name	D(1A) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd1
Synonym	D1 receptor D1A DADR dopamine D1 receptor Dopamine-1A receptor Gpcr15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProt	P18901
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL265
IUPHAR	214
DrugBank	N/A

Ligand

Name	diazepam
Molecular formula	C16H13ClN2O
IUPAC name	7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Molecular weight	284.743
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.0
Synonyms	Spectrum3_001780 Tensopam Tranquirit Valaxona Valuzepam W-5055 Zipan Sedipam Sibazon Diazemulus NCGC00260007-01 Anxionil Duksen Diazepam Elmu Nixtensyn Atilen Euphorin P Diazepam Stada NSC-77518 Benzopin FT-0632135 Diazepamu Paranten BRN 0754371 HMS503A15 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one Plidan Calmpose Jinpanfan Q-Pam Relanium Ceregulart LA 111 7-Chloro-1-methyl-5-3H-1,4-benzodiazepin-2(1H)-one Reliver D-Pam Lizan 7-Chloro-1-methyl-5-phenyl-2-oxo-2,3-dihydro-1H-benzo[f]-1,4-diazepine Diacepan Mentalium AB02310 Diazetard Diastat MLS001424086 AN-23449 Domalium Stesolid Tox21_202458 Trazepam Valitran Vazen Wy 3467 S.A.R.L. Serenack Simasedan Ansilive DSSTox_CID_406 Diazepam (JP17/USP/INN) Nervium Apozepam DZP Diazepam Intensol Novazam BCP0726000176 Faustal Diazepam, European Pharmacopoeia (EP) Reference Standard Oprea1_126223 Bialzepam Gradual Paxel C06948 HY-17027 2H-1, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- Pomin CC-26451 KBio3_002780 7-chloranyl-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Quiatril CHEMBL12 La-Iii 7-chloro-1-methyl-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one Ro 5-2807 D0Y1YC Mandro 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Diazepamum Dialar Methyldiazepinone AKOS003367969 Dipaz Diastat, Valium NC00247 Solis T-quil Tranqdyn Unisedil Valium R Vival Zepaxid SCHEMBL21442 Servizepam NCGC00178168-03 Antenex DTXSID4020406 Diazepam Dak NINDS_000967 Assival Elcion CR Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material NSC 169897 BDBM50000766 Freudal Diazepam-Lipuro Pacitran BRD-K16508793-001-01-8 HMS2051N04 Placidox 2 Calmociteno IDI1_000967 439-14-5 Psychopax Centrazepam Kratium 7-chloro-1-methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one Relaminal CPD000058398 Levium 7-Chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Desconet MCULE-8990989144 A826456 Diazepan leo Diapine Metil Gobanal Alupram DivK1c_000967 Diazem Spectrum4_000576 Tox21_113071 Tranquo-puren Valeo Vanconin Winii S.A. R.L Seduksen Sibazone Nellium Apaurin Dupin Diazepam Fabra Noan Azedipamin Eurosan Diazepam [USAN:INN:BAN:JAN] NSC169897 Best [Pharaceutical] Gewacalm Diazepamu [Polish] Parzam BSPBio_003279 Horizon 1-Methyl-5-phenyl-7-chloro-1,4-benzodiazepin-2-one Plumiaz CAS-439-14-5 Kabivitrum 53320-84-6 Q3JTX2Q7TU CHEBI:49575 LA III 7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one Renborin D00293 Lovium 7-Chloro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Diaceplex Metamidol AC-10561 Dienpax Diastat (TN) Mono (2-ethylhexyl) phthalate An-Ding Doval Stesolin Tranimul Umbrium Valium Vazepam WY-3467 SAM001246536 Serenamin Sipam Ansiolin DSSTox_GSID_20406 Diazepam 0.1 mg/ml in Methanol neurolytr il Armonil e-Pam Diazepam Nordic Novo-Dipam BCP23002 Faustan Diazepam, United States Pharmacopeia (USP) Reference Standard Ortopsique BIDD:GT0105 GTPL3364 Paxum Calmaven I06-0194 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- Pro pam CCG-100997 KBioGR_001012 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H -1,4-benzodiazepin-2-one Quievita Chuansuan Lamra 7-Chloro-1-methyl-5-phenyl-1,4-benzodiazepin-2-one Ro-52807 DB00829 Mandro-Zep 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one. Diazepamum [INN-Latin] Diapam Methyldiazepinone (pharmaceutical) Alboral Dipezona Diatran NCGC00178168-01 Sonacon Tensium Tranquase Usempax ap Valrelease Vivol ZINC6427 Sedapam Setonil Diazemuls NCGC00178168-04 Anxicalm Ducene Diazepam Desitin Nivalen Atensine Eridan Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis NSC-169897 Bensedin Frustan Diazepam-ratiopharm Paralium Britazepam HMS3393N04 (Z)-7-chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Placidox 5 Calmod InChI=1/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H 5-24-04-00300 (Beilstein Handbook Reference) Q-pam Cercine Kratium 2 7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine Relanium CS-0653 Liberetas 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one Desloneg Medipam AAOVKJBEBIDNHE-UHFFFAOYSA-N Diazepin Diaquel MLS000759402 Amiprol Dizac Spectrum5_001890 Tox21_113071_1 Tranquo-tablinen Valiquid Vatran WLN: T67 GNV JN IHJ CG G1 KR S.a. r.l. Seduxen Sico Relax Diazepam (intranasal, epilepsy) Nerozen Apo-diazepam Duxen Diazepam for system suitability, European Pharmacopoeia (EP) Reference Standard Notense Baogin Evacalm Diazepam [USAN:USP:INN:BAN:JAN] NSC77518 Betapam Gihitan Paxate C-17931 HSDB 3057 11100-37-1 Pms-Diazepam Caudel KBio1_000967 7 -chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Quetinil LA-111 7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one Ro 5-2805 D07JVL LS-122 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one Dialag Methyl diazepinone AC1L1EZE Dipam Diastat Acudial Morosan Anlin Drenian SMR000058398 STK735517 Trankinon UNII-Q3JTX2Q7TU Valium (TN) Velium ZB000640 Saromet Serenzin Ansiolisina DSSTox_RID_75566 Diazepam 1.0 mg/ml in Methanol Neurolytril Arzepam EINECS 207-122-5 Diazepam Rectubes Novodipam BCP9000199 Faustan, Diazepam-Eurogenerics Paceum BIDD:PXR0158 Gubex Placidox 10 Calmocitene Iazepam Prozepam CCRIS 6009 Kiatrium 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Radizepam Condition Lembrol 7-chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2(3H)on Ruhsitus DEA No. 2765 Mandrozep A3662/0155188 Diazepan Diapax Methyldiazepinone, pharmaceutical Aliseum Disopam Diazapam NCGC00178168-02 [ Show all ]
Inchi Key	AAOVKJBEBIDNHE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
PubChem CID	3016
ChEMBL	CHEMBL12
IUPHAR	3364
BindingDB	50000766
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID6387355	BindingDB

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