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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 183
Species	Mus musculus (Mouse)
Gene	Gpr183
Synonym	GPR183 G protein-coupled receptor 183 Epstein-Barr virus-induced gene 2 Epstein-Barr virus-induced G-protein coupled receptor 2 homolog {ECO:0000250\|UniProtKB:P32249} EBV-induced G-protein coupled receptor 2 homolog {ECO:0000250\|UniProtKB:P32249} EBV-induced G protein-coupled receptor 2 EBI2 {ECO:0000250\|UniProtKB:P32249} EBI2 lymphocyte-specific G protein-coupled receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MANNFTTPLATSHGNNCDLYAHHSTARVLMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSMNLVISDILFTTALPTRIAYYALGFDWRIGDALCRVTALVFYINTYAGVNFMTCLSIDRFFAVVHPLRYNKIKRIEYAKGVCLSVWILVFAQTLPLLLTPMSKEEGDKTTCMEYPNFEGTASLPWILLGACLLGYVLPITVILLCYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFILCFTPYHVAIIQHMIKMLCSPGALECGARHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMKMLKRQVSVSISSAVRSAPEENSREMTESQMMIHSKASNGR
UniProt	Q3U6B2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259471
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1305842
Molecular formula	C20H21ClN2O3
IUPAC name	1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]-2-phenylethanone
Molecular weight	372.849
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.9
Synonyms	2-(4-chlorophenoxy)-1-[4-(2-phenylacetyl)tetrahydro-1-pyrazinyl]-1-ethanone Oprea1_016284 AC1LLRD1 HMS2331B03 ZINC779562 1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]-2-phenylethanone BAS 04057128 MLS002540233 2-(4-chlorophenoxy)-1-[4-(phenylacetyl)piperazin-1-yl]ethanone SMR000070468 1-[(4-chlorophenoxy)acetyl]-4-(phenylacetyl)piperazine AKOS000550821 MCULE-9771349745 1-{4-[2-(4-Chloro-phenoxy)-acetyl]-piperazin-1-yl}-2-phenyl-ethanone BDBM50011718 MolPort-001-623-749 EU-0046770 STK146408 1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]-2-phenyl-ethanone AT-057/43316466 MLS000099053 [ Show all ]
Inchi Key	XUWONGFKJGXWMM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H21ClN2O3/c21-17-6-8-18(9-7-17)26-15-20(25)23-12-10-22(11-13-23)19(24)14-16-4-2-1-3-5-16/h1-9H,10-15H2
PubChem CID	1072066
ChEMBL	CHEMBL1305842
IUPHAR	N/A
BindingDB	50011718
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	977.0 nM	PMID24678947	BindingDB
IC50	977.24 nM	PMID24678947	ChEMBL
IC50	979.0 nM	PMID24678947	ChEMBL

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