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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2392180
Molecular formula	C21H17NO6
IUPAC name	8-[[4-(cyclopropylmethoxy)benzoyl]amino]-4-oxochromene-2-carboxylic acid
Molecular weight	379.368
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.8
Synonyms	BDBM50440044
Inchi Key	XLFXGGJNLVVLDM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H17NO6/c23-17-10-18(21(25)26)28-19-15(17)2-1-3-16(19)22-20(24)13-6-8-14(9-7-13)27-11-12-4-5-12/h1-3,6-10,12H,4-5,11H2,(H,22,24)(H,25,26)
PubChem CID	71733937
ChEMBL	CHEMBL2392180
IUPHAR	N/A
BindingDB	50440044
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	10.0 %	PMID23713606	ChEMBL
Ki	3710.0 nM	PMID23888932	BindingDB,ChEMBL

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