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GPCR

NameP2Y purinoceptor 14
SpeciesHomo sapiens (Human)
GeneP2RY14
SynonymG-protein coupled receptor 105
GPR105
G protein-coupled receptor 105
P2Y purinoceptor 14
P2Y14
[ Show all ]
DiseaseN/A
Length338
Amino acid sequenceMINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
UniProtQ15391
Protein Data BankN/A
GPCR-HGmod modelQ15391
3D structure modelThis predicted structure model is from GPCR-EXP Q15391.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4518
IUPHAR330
DrugBankN/A

Ligand

NameCHEMBL1162553
Molecular formulaC12H23N3O11P2S
IUPAC nameazane;[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] propyl hydrogen phosphate
Molecular weight479.334
Hydrogen bond acceptor13
Hydrogen bond donor6
XlogPNone
SynonymsN/A
Inchi KeyXIRYSGIWTQTDST-VYFIMUGFSA-N
Inchi IDInChI=1S/C12H20N2O11P2S.H3N/c1-2-5-22-26(18,19)25-27(20,21)23-6-7-9(16)10(17)11(24-7)14-4-3-8(15)13-12(14)28;/h3-4,7,9-11,16-17H,2,5-6H2,1H3,(H,18,19)(H,20,21)(H,13,15,28);1H3/t7-,9-,10-,11-;/m1./s1
PubChem CID44627592
ChEMBLCHEMBL1162553
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
EC5040.0 nMPMID19902968ChEMBL

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