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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 1B
Species	Cricetulus griseus (Chinese hamster)
Gene	HTR1B
Synonym	5-HT-1B 5-HT1B Serotonin receptor 1B
Disease	N/A for non-human GPCRs
Length	386
Amino acid sequence	MEEQGIQCAPPPPAASQTGVPLVNLSHNCSAESHIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPVSTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVEYAAKRTPKRAAIMIALVWVFSISISLPPFFWRQAKAEEEVLTCLVNTDHVLYTVYSTGGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTTSVTSINSRAPDLPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMATLDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCAG
UniProt	P46636
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3707466
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL931346
Molecular formula	C26H27N5O2
IUPAC name	7-[4-(2-pyridin-2-ylethyl)piperazin-1-yl]-N-(pyridin-2-ylmethyl)-1-benzofuran-2-carboxamide
Molecular weight	441.535
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.3
Synonyms	US8859534, 1 7-(4-(2-(Pyridin-2-yl)ethyl)piperazin-1-yl)-N-(pyridin-2-ylmethyl)benzofuran-2-carboxamide CHEMBL3647259 XIKBBDZPWPLOFN-UHFFFAOYSA-N BDBM136315
Inchi Key	XIKBBDZPWPLOFN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H27N5O2/c32-26(29-19-22-8-2-4-12-28-22)24-18-20-6-5-9-23(25(20)33-24)31-16-14-30(15-17-31)13-10-21-7-1-3-11-27-21/h1-9,11-12,18H,10,13-17,19H2,(H,29,32)
PubChem CID	59636772
ChEMBL	CHEMBL3647259
IUPHAR	N/A
BindingDB	136315
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	19.0 nM	, None	BindingDB,ChEMBL

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