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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Leukotriene B4 receptor 1
Species	Homo sapiens (Human)
Gene	LTB4R
Synonym	BLT1 receptor BLTR Chemoattractant receptor-like 1 G-protein coupled receptor 16 GPR16 P2Y7 P2Y purinoceptor 7 LTB4-R1 LTB4-R 1 [ Show all ]
Disease	Inflammatory disease Inflammatory bowel disease Human immunodeficiency virus infection Pancreatic cancer Psoriasis Cystic fibrosis Osteoporosis Renal cancer Rheumatoid arthritis Asthma Allergy [ Show all ]
Length	352
Amino acid sequence	MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
UniProt	Q15722
Protein Data Bank	N/A
GPCR-HGmod model	Q15722
3D structure model	This predicted structure model is from GPCR-EXP Q15722.
BioLiP	N/A
Therapeutic Target Database	T59626
ChEMBL	CHEMBL3911
IUPHAR	267
DrugBank	BE0003490

Ligand

Name	CHEMBL262530
Molecular formula	C28H36O7
IUPAC name	(2R)-7-[3-[4-acetyl-3-(hydroxymethyl)-2-propylphenoxy]propoxy]-8-propyl-3,4-dihydro-2H-chromene-2-carboxylic acid
Molecular weight	484.589
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	5.4
Synonyms	BDBM50088246 7-[3-(4-Acetyl-3-hydroxymethyl-2-propyl-phenoxy)-propoxy]-8-propyl-chroman-2-carboxylic acid
Inchi Key	AEWRVVLKZHESHF-AREMUKBSSA-N
Inchi ID	InChI=1S/C28H36O7/c1-4-7-21-23(17-29)20(18(3)30)11-14-24(21)33-15-6-16-34-25-12-9-19-10-13-26(28(31)32)35-27(19)22(25)8-5-2/h9,11-12,14,26,29H,4-8,10,13,15-17H2,1-3H3,(H,31,32)/t26-/m1/s1
PubChem CID	44302966
ChEMBL	CHEMBL262530
IUPHAR	N/A
BindingDB	50088246
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	320.0 nM	PMID10821712	BindingDB,ChEMBL

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