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GPCR

NameG-protein coupled receptor 182
SpeciesHomo sapiens (Human)
GeneGPR182
SynonymNOW
L1-R
GPR182
Gpcr22
Gpcr17
[ Show all ]
DiseaseN/A
Length404
Amino acid sequenceMSVKPSWGPGPSEGVTAVPTSDLGEIHNWTELLDLFNHTLSECHVELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGIVLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASPSWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVEGPEPMCLFMAPFETYSTWALAVALSTTILGFLLPFPLITVFNVLTACRLRQPGQPKSRRHCLLLCAYVAVFVMCWLPYHVTLLLLTLHGTHISLHCHLVHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNAVVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPS
UniProtO15218
Protein Data BankN/A
GPCR-HGmod modelO15218
3D structure modelThis predicted structure model is from GPCR-EXP O15218.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4356
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL371823
Molecular formulaC23H28N4O6
IUPAC name1-N',7-N'-bis(2-phenoxyacetyl)heptanedihydrazide
Molecular weight456.499
Hydrogen bond acceptor6
Hydrogen bond donor4
XlogP2.4
SynonymsN/A
Inchi KeyXHANEBRMODXIFB-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H28N4O6/c28-20(24-26-22(30)16-32-18-10-4-1-5-11-18)14-8-3-9-15-21(29)25-27-23(31)17-33-19-12-6-2-7-13-19/h1-2,4-7,10-13H,3,8-9,14-17H2,(H,24,28)(H,25,29)(H,26,30)(H,27,31)
PubChem CID11487891
ChEMBLCHEMBL371823
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Affinity16.0 %PMID15943480ChEMBL

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