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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL2159344
Molecular formula	C33H33Cl2N3O3
IUPAC name	3-[[4-[1-[5-(2-cyclohexylphenyl)-3-(3,5-dichlorophenyl)pyrazol-1-yl]ethyl]benzoyl]amino]propanoic acid
Molecular weight	590.545
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	8.1
Synonyms	BDBM50393790
Inchi Key	CCXJPCNMWZNEFC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C33H33Cl2N3O3/c1-21(22-11-13-24(14-12-22)33(41)36-16-15-32(39)40)38-31(20-30(37-38)25-17-26(34)19-27(35)18-25)29-10-6-5-9-28(29)23-7-3-2-4-8-23/h5-6,9-14,17-21,23H,2-4,7-8,15-16H2,1H3,(H,36,41)(H,39,40)
PubChem CID	71454981
ChEMBL	CHEMBL2159344
IUPHAR	N/A
BindingDB	50393790
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	337.0 nM	PMID22708876	BindingDB
IC50	337.4 nM	PMID22708876	ChEMBL
IC50	362.0 nM	PMID22708876	BindingDB,ChEMBL

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