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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL179181
Molecular formula	C23H27Cl2N3OS
IUPAC name	N-[3-cyano-6-[(2,4-dichlorophenyl)methyl-methylamino]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-2-ethylbutanamide
Molecular weight	464.449
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	6.7
Synonyms	BDBM50161496 N-{3-Cyano-6-[(2,4-dichloro-benzyl)-methyl-amino]-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl}-2-ethyl-butyramide
Inchi Key	CCPYJKBUUNBZNC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H27Cl2N3OS/c1-4-14(5-2)22(29)27-23-19(12-26)18-9-8-17(11-21(18)30-23)28(3)13-15-6-7-16(24)10-20(15)25/h6-7,10,14,17H,4-5,8-9,11,13H2,1-3H3,(H,27,29)
PubChem CID	44389632
ChEMBL	CHEMBL179181
IUPHAR	N/A
BindingDB	50161496
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	63.0 nM	PMID15713396	BindingDB,ChEMBL
IC50	92.0 nM	PMID15713396	BindingDB,ChEMBL

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