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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Gallus gallus (Chicken)
Gene	CHRM4
Synonym	N/A
Disease	N/A for non-human GPCRs
Length	490
Amino acid sequence	MHNLSAQPWQAKMANLTYDNVTLSNRSEVAIQPPTNYKTVELVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWILSFILWAPAILFWQFIVGKRTVHERECYIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVRRHKPESRKERKGKSLSFFKAPPVKQNNNNSPKRAVEVKEEVRNGKVDDQPSAQTEATGQQEEKETSNESSTVSMTQTTKDKPTTEILPAGQGQSPAHPRVNPTSKWSKIKIVTKQTGTESVTAIEIVPAKAGASDHNSLSNSRPANVARKFASIARSQVRKKRQMAAREKKVTRTIFAILLAFILTWTPYNVMVLINTFCETCVPETVWSIGYWLCYVNSTINPACYALCNATFKKTFKHLLMCQYRNIGTAR
UniProt	P17200
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	procyclidine
Molecular formula	C19H29NO
IUPAC name	1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
Molecular weight	287.447
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.1
Synonyms	KBio2_003910 Lergine NSC169103 Procidlidina Procyklidin 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol Spectrum3_000557 AB00053533 Vagosin BDBM50062598 CHEBI:8448 DTXSID2023515 GTPL7280 KBioGR_000977 NCGC00018186-02 Prestwick1_000844 1-Cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol SCHEMBL147344 107661-03-0 Spectrum_000862 AC1L1J8M BRD-A31800922-003-15-2 D08425 KBio1_000429 Kemadrine NSC 169103 Prociclidina Procyclidinum 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol hydrochloride SPBio_002748 56172-67-9 Tricoloid API0008986 BSPBio_002233 DB00387 EINECS 201-023-0 KBio2_006478 LS-138139 Osnervan Procyclid Prosyklidin 1-Pyrrolidinepropanol, .alpha.-cyclohexyl-.alpha.-phenyl- Spectrum4_000489 AB00053533_15 WLN: T5NTJ A2XQR&- AL6TJ BPBio1_000911 HSDB 7678 KBioSS_001342 NCGC00018186-04 Prestwick2_000844 Procyclidine (INN) 1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol Spamol 5-20-01-00250 (Beilstein Handbook Reference) Triciclidina AC1Q76Z5 BRN 0088563 D0R1WR KBio2_001342 L001290 NSC-169103 Prociclidina [INN-Spanish] Procyclidinum [INN-Latin] 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol Spectrum2_001298 77-37-2 Tricyclamol Arpicolin C07378 DivK1c_000429 Elorine KBio3_001733 Metanin Prestwick0_000844 Procyclidin .alpha.-Cyclohexyl-.alpha.-phenyl-1-pyrrolidinepropanol SBI-0051493.P003 1-PYRROLIDINEPROPANOL, alpha-CYCLOHEXYL-alpha-PHENYL- Spectrum5_001224 AB00053533_16 WYDUSKDSKCASEF-UHFFFAOYSA-N BRD-A31800922-003-05-3 CHEMBL86715 IDI1_000429 Kemadrin NINDS_000429 Prestwick3_000844 Procyclidine [INN:BAN] 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol SPBio_001335 Triciloid AC1Q77DP BSPBio_000827 [ Show all ]
Inchi Key	WYDUSKDSKCASEF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2
PubChem CID	4919
ChEMBL	CHEMBL86715
IUPHAR	N/A
BindingDB	50062598
DrugBank	DB00387
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	6.03 nM	PMID2250662	BindingDB

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