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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Homo sapiens (Human)
Gene	PTGER2
Synonym	PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 EP2 receptor [ Show all ]
Disease	Osteoporosis Pulmonary arterial hypertension Miscarriage Medical abortion Immune disorder Glaucoma Solid tumours Endometriosis Diabetic foot ulcer Cancer [ Show all ]
Length	358
Amino acid sequence	MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProt	P43116
Protein Data Bank	N/A
GPCR-HGmod model	P43116
3D structure model	This predicted structure model is from GPCR-EXP P43116.
BioLiP	N/A
Therapeutic Target Database	T38529
ChEMBL	CHEMBL1881
IUPHAR	341
DrugBank	BE0000368

Ligand

Name	CHEMBL314200
Molecular formula	C30H31NO5S2
IUPAC name	2-methyl-3-[2-[4-[3-(3-methylphenoxy)propoxy]phenyl]phenyl]-N-thiophen-2-ylsulfonylpropanamide
Molecular weight	549.7
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	7.1
Synonyms	BDBM50117687 N-(2-Thienylsulfonyl)-alpha-methyl-4'-[3-(3-methylphenoxy)propoxy]biphenyl-2-propionamide SCHEMBL7247722 Thiophene-2-sulfonic acid {2-methyl-3-[4''-(3-m-tolyloxy-propoxy)-biphenyl-2-yl]-propionyl}-amide
Inchi Key	CCCNLSVRJPFWGZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H31NO5S2/c1-22-8-5-10-27(20-22)36-18-7-17-35-26-15-13-24(14-16-26)28-11-4-3-9-25(28)21-23(2)30(32)31-38(33,34)29-12-6-19-37-29/h3-6,8-16,19-20,23H,7,17-18,21H2,1-2H3,(H,31,32)
PubChem CID	12112239
ChEMBL	CHEMBL314200
IUPHAR	N/A
BindingDB	50117687
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2900.0 nM	PMID12182865	BindingDB,ChEMBL

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