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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Homo sapiens (Human)
Gene	CHRM4
Synonym	HM3 M4 receptor cholinergic receptor Chrm-4 cholinergic receptor, muscarinic 4
Disease	Produce mydriasis and cycloplegia for diagnostic purposes Hypertension Irritable bowel syndrome Moderate and severe psychomotor agitation Mydriasis diagnosis Nausea; Vomiting; Emesis Organophosphate poisoning Overactive bladder disorder; Spasm Parkinson's disease Urinary retention Peptic ulcer Peptic ulcer disease; Irritable bowel syndrome; Pancreatitis; Gastritis Solid tumours Peptic ulcer; Gastrointestinal disease Peptic ulcer; Uveitis Glaucoma Gastrointestinal disease Bronchodilator Poison intoxication Chronic obstructive pulmonary disease Cough Central and peripheral nervous diseases Depression Alzheimer disease Dysuria; Urgency; Nocturia; Suprapubic pain Gastric motility disorder; Spasm Acquired nystagmus [ Show all ]
Length	479
Amino acid sequence	MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProt	P08173
Protein Data Bank	5dsg
GPCR-HGmod model	P08173
3D structure model	This structure is from PDB ID 5dsg.
BioLiP	BL0339919,BL0339921, BL0339920
Therapeutic Target Database	T20709, T50918
ChEMBL	CHEMBL1821
IUPHAR	16
DrugBank	BE0000405

Ligand

Name	4-Damp methiodide
Molecular formula	C21H26INO2
IUPAC name	(1,1-dimethylpiperidin-1-ium-4-yl) 2,2-diphenylacetate;iodide
Molecular weight	451.348
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	None
Synonyms	CHEBI:73340 HMS3266E10 N,N-dimethyl-4-(diphenylacetoxy)piperidinium iodide SR-01000075326-1 1,1-dimethyl-4-diphenylacetoxypiperidinium iodide 4-DAMP methyliodide AC1MHZ3P BN0026 D-104 LP00407 Piperidinium, 4-((diphenylacetyl)oxy)-1,1-dimethyl-, iodide 4-((Diphenylacetyl)oxy)-1,1-dimethylpiperidinium iodide 4-DIPHENYLACETOXY-N-METHYL-PIPERIDINE METHIODIDE CCG-221711 HMS2234J07 MLS000859984 SMR000326843 4-DAMP iodide 4-[(Diphenylacetyl)oxy]-1,1-dimethyl-piperidinium iodide HMS3369K06 NCGC00093833-01 SR-01000075326-3 1,1-dimethyl-4-diphenylacetoxypiperidiniumiodide 4-DAMP, >=98% (HPLC) AKOS024458363 C-56134 EU-0100407 LS-173781 REGID_for_CID_3014059 4-(2,2-diphenylacetoxy)-1,1-dimethylpiperidinium iodide 4-Diphenylacetoxy-N-methylpiperidine methiodide CCG-222526 HMS3261A16 MolPort-003-940-940 SR-01000075326 (1,1-dimethylpiperidin-1-ium-4-yl) 2,2-diphenylacetate iodide 81405-11-0 (Parent) CHEMBL76897 J-012645 NCGC00261092-01 Tox21_500407 1952-15-4 4-diphenylacetoxy-1,1-dimethylpiperidinium iodide B6317 C21H26NO2.I FT-0742369 MFCD00078564 SCHEMBL3987354 4-DAMP 4-[(2,2-diphenylacetyl)oxy]-1,1-dimethylpiperidin-1-ium iodide [ Show all ]
Inchi Key	WWJHRSCUAQPFQO-UHFFFAOYSA-M
Inchi ID	InChI=1S/C21H26NO2.HI/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;/h3-12,19-20H,13-16H2,1-2H3;1H/q+1;/p-1
PubChem CID	3014059
ChEMBL	CHEMBL76897
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.49 nM	PMID26988801, PMID27876250	ChEMBL
IC50	0.61 nM	PMID23466604	ChEMBL
IC50	0.83 nM	PMID23582449	ChEMBL
IC50	1.1 nM	PMID18983139	ChEMBL
Ki	0.37 nM	PMID23466604	ChEMBL
Ki	0.5129 nM	Bioorg. Med. Chem. Lett., (1995) 5:20:2325	ChEMBL
Ki	0.66 nM	PMID18983139	ChEMBL
Ki	0.88 nM	PMID24805037	ChEMBL

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