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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Leukotriene B4 receptor 1
Species	Homo sapiens (Human)
Gene	LTB4R
Synonym	BLT1 receptor BLTR Chemoattractant receptor-like 1 G-protein coupled receptor 16 GPR16 P2Y7 P2Y purinoceptor 7 LTB4-R1 LTB4-R 1 [ Show all ]
Disease	Inflammatory disease Inflammatory bowel disease Human immunodeficiency virus infection Pancreatic cancer Psoriasis Cystic fibrosis Osteoporosis Renal cancer Rheumatoid arthritis Asthma Allergy [ Show all ]
Length	352
Amino acid sequence	MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
UniProt	Q15722
Protein Data Bank	N/A
GPCR-HGmod model	Q15722
3D structure model	This predicted structure model is from GPCR-EXP Q15722.
BioLiP	N/A
Therapeutic Target Database	T59626
ChEMBL	CHEMBL3911
IUPHAR	267
DrugBank	BE0003490

Ligand

Name	CHEMBL134697
Molecular formula	C23H26N2O3
IUPAC name	6-[4-(4-aminophenyl)quinolin-2-yl]oxy-2,2-dimethylhexanoic acid
Molecular weight	378.472
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	4.9
Synonyms	BDBM50001616 SCHEMBL8987115 6-[4-(4-Amino-phenyl)-quinolin-2-yloxy]-2,2-dimethyl-hexanoic acid
Inchi Key	CCAHDZNXPZTVOL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H26N2O3/c1-23(2,22(26)27)13-5-6-14-28-21-15-19(16-9-11-17(24)12-10-16)18-7-3-4-8-20(18)25-21/h3-4,7-12,15H,5-6,13-14,24H2,1-2H3,(H,26,27)
PubChem CID	9999718
ChEMBL	CHEMBL134697
IUPHAR	N/A
BindingDB	50001616
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	40.0 nM	PMID1333011	BindingDB,ChEMBL
IC50	250.0 nM	PMID1333011	BindingDB,ChEMBL

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