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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Rattus norvegicus (Rat)
Gene	Chrm2
Synonym	cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor M2 receptor cholinergic receptor, muscarinic 2, cardiac [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P10980
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL309
IUPHAR	14
DrugBank	N/A

Ligand

Name	CHEMBL360491
Molecular formula	C24H26N2O2
IUPAC name	1-[4-(diethylamino)but-2-ynyl]-3,3-diphenylpyrrolidine-2,5-dione
Molecular weight	374.484
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.2
Synonyms	1-(4-Diethylamino-but-2-ynyl)-3,3-diphenyl-pyrrolidine-2,5-dione BDBM50291596
Inchi Key	CBISQPJLYSUKOF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H26N2O2/c1-3-25(4-2)17-11-12-18-26-22(27)19-24(23(26)28,20-13-7-5-8-14-20)21-15-9-6-10-16-21/h5-10,13-16H,3-4,17-19H2,1-2H3
PubChem CID	10248845
ChEMBL	CHEMBL360491
IUPHAR	N/A
BindingDB	50291596
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	380.0 nM	, Bioorg. Med. Chem. Lett., (1997) 7:8:979	BindingDB,ChEMBL

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