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GPCR

NameNeuropeptide FF receptor 2
SpeciesRattus norvegicus (Rat)
GeneNpffr2
SynonymF8Famide receptor
G protein-coupled receptor 74
G-protein coupled receptor 74
GPR74
Neuropeptide G-protein coupled receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length417
Amino acid sequenceMGKRWDSNSSGSWDHIWSGNDTQHPWYSDINITYMNYYLHQPHVTAVFISSYFLIFFLCMVGNTVVCFVVIRNRYMHTVTNFFIFNLAISDLLVGIFCMPITLLDNIIAGWPFGSSMCKISGLVQGISVAASVFTLVAIAVDRFRCVVYPFKPKLTVKTAFVMIVIIWGLAITIMTPSAIMLHVQEEKYYRVRLSSHNKTSTVYWCREDWPNQEMRRIYTTVLFATIYLAPLSLIVIMYARIGASLFKTSAHSTGKQRLEQWHVSKKKQKVIKMLLTVALLFILSWLPLWTLMMLSDYADLSPNKLRVINIYVYPFAHWLAFCNSSVNPIIYGFFNENFRSGFQDAFQFCQKKVKPQEAYGLRAKRNLDINTSGLLVHEPASQNPSGENLGCRKSADNPTQESLMEETGEATNSTET
UniProtQ9EQD2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3425
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2181025
Molecular formulaC65H99N19O14S
IUPAC name(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-4-methylsulfanylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]butanediamide
Molecular weight1402.69
Hydrogen bond acceptor18
Hydrogen bond donor17
XlogP-1.4
SynonymsN/A
Inchi KeyWODYPTOYYNUKAS-BDTMIGBKSA-N
Inchi IDInChI=1S/C65H99N19O14S/c1-35(2)26-45(57(91)74-37(5)54(88)78-46(27-36(3)4)59(93)76-43(20-14-23-72-65(69)70)56(90)77-44(53(68)87)28-39-16-10-8-11-17-39)80-61(95)49(31-52(67)86)79-55(89)38(6)75-58(92)47(29-40-18-12-9-13-19-40)81-62(96)50(33-85)83-60(94)48(30-41-32-71-34-73-41)82-63(97)51-21-15-24-84(51)64(98)42(66)22-25-99-7/h8-13,16-19,32,34-38,42-51,85H,14-15,20-31,33,66H2,1-7H3,(H2,67,86)(H2,68,87)(H,71,73)(H,74,91)(H,75,92)(H,76,93)(H,77,90)(H,78,88)(H,79,89)(H,80,95)(H,81,96)(H,82,97)(H,83,94)(H4,69,70,72)/t37-,38-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1
PubChem CID71457397
ChEMBLCHEMBL2181025
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition54.0 %PMID22909119ChEMBL
Inhibition55.0 %PMID22909119ChEMBL
Inhibition67.0 %PMID22909119ChEMBL

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