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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Rattus norvegicus (Rat)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	436
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProt	P31388
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3372
IUPHAR	11
DrugBank	N/A

Ligand

Name	5-Benzyloxytryptamine
Molecular formula	C17H18N2O
IUPAC name	2-(5-phenylmethoxy-1H-indol-3-yl)ethanamine
Molecular weight	266.344
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	2.0
Synonyms	2-(5-benzyloxy-1H-indol-3-yl)ethanamine 2-[5-(phenylmethoxy)indol-3-yl]ethylamine 5-Benzyloxytriptamine AC1L3I5U BB 0242425 CTK4E5072 Jsp004257 NCGC00246513-01 ST50308182 2-[5-(benzyloxy)-1H-indol-3-yl]ethanamine 3-(2-aminoethyl)-5-benzyloxyindole 5-Benzyloxytryptamine, free base ALBB-006771 CAS_20776-45-8 EINECS 257-626-4 L000876 PDSP2_000757 WKPDXBXNJWWWGQ-UHFFFAOYSA-N 2-[5-(Benzyloxy)-1H-indol-3-yl]ethylamine # 5-Benzyloxy-3-(2-ethylamino)indole hydrochloride B-2100 CCG-20533 GTPL265 MLS000762453 SCHEMBL2537373 2-(5-(Benzyloxy)-1H-indol-3-yl)ethanamine 2-(5-benzyloxy-1h-indol-3-yl)ethylamine 20776-45-8 5-Benzyloxytriptamine HCl AJ-09599 BBL001424 D06NGQ KB-163149 Oprea1_485666 STK500562 2-[5-(benzyloxy)-1H-indol-3-yl]ethanamine hydrochloride 5-(Phenylmethoxy)-1H-indole-3-ethylamine monohydrochloride 5-BT AN-7305 CB-249 EU-0045275 LS-82273 R1244 ZINC57128 1H-Indole-3-ethanamine, 5-(phenylmethoxy)- 2-[5-(phenylmethoxy)-1H-indol-3-yl]ethanamine 5-benzyloxy-tryptamine A-7289 B19458 CHEMBL1288652 HMS2808A18 MolPort-001-779-632 SMR000437938 2-(5-Benzyloxy-1H-indol-3-yl)-ethylamine 2-(5-phenylmethoxy-1H-indol-3-yl)ethanamine AKOS001676606 BDBM82302 EINECS 244-024-1 KB-177042 PDSP1_000769 TR-018512 2-[5-(Benzyloxy)-1H-indol-3-yl]ethylamine 5-benzyloxy tryptamine 5-BZT AS-47706 CBDivE_004615 FT-0620055 MCULE-8280916549 SBB003066 ZX-AN006412 1H-Indole-3-ethanamine,5-(phenylmethoxy)- [ Show all ]
Inchi Key	WKPDXBXNJWWWGQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H18N2O/c18-9-8-14-11-19-17-7-6-15(10-16(14)17)20-12-13-4-2-1-3-5-13/h1-7,10-11,19H,8-9,12,18H2
PubChem CID	89576
ChEMBL	N/A
IUPHAR	265
BindingDB	82302
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	63.0957 - 316.228 nM	PMID7680751, PMID9225298, PMID9798944	IUPHAR
Ki	109.64 nM	PMID7984267	BindingDB
Ki	110.0 nM	PMID7680751	BindingDB
Ki	295.12 nM	PMID9225298	BindingDB

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