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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Metabotropic glutamate receptor 4
Species	Homo sapiens (Human)
Gene	GRM4
Synonym	mGluR4 mGlu4 receptor GPRC1D glutamate receptor
Disease	Anxiety disorder Neurological disease
Length	912
Amino acid sequence	MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
UniProt	Q14833
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T99402
ChEMBL	CHEMBL2736
IUPHAR	292
DrugBank	BE0000833

Ligand

Name	SCHEMBL11235794
Molecular formula	C5H9NO4
IUPAC name	(2S)-2-amino-5-hydroxy-5-oxopentanoate;hydron
Molecular weight	147.13
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	None
Synonyms	N/A
Inchi Key	WHUUTDBJXJRKMK-VKHMYHEASA-N
Inchi ID	InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
PubChem CID	88747398
ChEMBL	CHEMBL575060
IUPHAR	1369
BindingDB	17657
DrugBank	DB00142
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
Activity	12000.0 nM	PMID12166935	ChEMBL
EC50	3162.28 - 19952.6 nM	PMID10443583	IUPHAR
EC50	3200.0 nM	MedChemComm, (2011) 2:11:1120	ChEMBL
EC50	9800.0 nM	PMID9572889	ChEMBL
EC50	15000.0 nM	PMID8759641	BindingDB,ChEMBL
EC50	20000.0 nM	PMID7738999	BindingDB,ChEMBL
Ki	1400.0 nM	PMID19042134	BindingDB,ChEMBL
Ki	1600.0 nM	PMID12109902	ChEMBL
Ki	2400.0 nM	PMID17725337	BindingDB,ChEMBL
Ki	3000.0 nM	PMID9131252	BindingDB
Ki	3235.94 nM	MedChemComm, (2011) 2:11:1120	ChEMBL
Ki	17000.0 nM	PMID10893301	BindingDB,ChEMBL
Ratio	20.0 -	PMID12109902	ChEMBL

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