Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Metabotropic glutamate receptor 5
Species	Rattus norvegicus (Rat)
Gene	Grm5
Synonym	glutamate receptor GPRC1E mGlu5 receptor mGluR5
Disease	N/A for non-human GPCRs
Length	1203
Amino acid sequence	MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLRSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFAQENSKYNKTCNSSLTLRTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLDSLMKTNFTGVSGDMILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKNNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSTRGQHLWQRLSVHINKKENPNQTAVIKPFPKSTENRGPGAAAGGGSGPGVAGAGNAGCTATGGPEPPDAGPKALYDVAEAEESFPAAARPRSPSPISTLSHLAGSAGRTDDDAPSLHSETAARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAATPGPPGTPICSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQGATGVSPAQETPTGAESAPGKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL
UniProt	P31424
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2564
IUPHAR	293
DrugBank	N/A

Ligand

Name	D-glutamic acid
Molecular formula	C5H9NO4
IUPAC name	(2R)-2-aminopentanedioic acid
Molecular weight	147.13
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-3.7
Synonyms	AC-24113 MolPort-002-499-418 ANW-35567 PDSP1_000131 CHEBI:15966 Q479989WEA D-(-)-Glutamic acid SC-09473 TL806175 D0O1AK delta-Glutamic acid E620 glutamate (r)-glutamic acid HY-100805 L(+)-Glutamic acid AI3-09072 NCGC00024501-02 Biomol-NT_000169 PDSP2_001470 CHEMBL76232 R-(-)-Glutamic acid D-2-Aminopentanedioate SR-01000597732 D-Glutamic acid, Vetec(TM) reagent grade, >=99% UNII-61LJO5I15S component WHUUTDBJXJRKMK-GSVOUGTGSA-N delta-2-Aminoglutarate delta-Glutaminsaeure FT-0624571 (r)-1-aminopropane-1,3-dicarboxylic acid glutamic acid d- 6893-26-1 AB1001986 M02964 AKOS015854118 NSC 77686 C00217 PubChem10977 D(-)-Glutamic acid RTC-066721 D-Glu ST2406765 D-Glutaminsaeure Z-0144 delta-2-Aminopentanedioic acid DSSTox_GSID_48675 gamma-poly(D-glutamic acid) macromolecule (R)-2-aminopentanedioate GTPL4708 KS-00000A9T AC1L2M41 NCGC00015470-01 AS-12791 PDSP1_001486 CHEBI:53375 R-(-)-1-Aminopropane-1,3-dicarboxylic acid D-2-Aminoglutarate SC-49449 D-Glutamic acid, >=99% Tocris-0217 D0YB9P delta-Glutaminate EINECS 230-000-8 (2R)-2-aminopentanedioic acid GLUTAMIC ACID 138-16-9 Lopac-G-2128 AJ-24146 NCGC00024501-03 BPBio1_001130 poly(D-glutamicacid) CS-6255 R-(?)-1-Aminopropane-1,3-dicarboxylic acid D-2-Aminopentanedioic acid SR-01000597732-1 D-Glutamicacid UNII-Q479989WEA delta-2-Aminoglutaric acid DGL G0057 (R)-2-Aminoglutaric acid Glutamic acid D-form 893G261 AC-15064 MFCD00063112 AM20100640 PDGA CAS-6893-26-1 Q-100774 D(-)-Glutamic acid, 99+% SBB006707 D-glutamate TC-066721 D-[14C]Glu ZINC895124 delta-Glutamate DSSTox_RID_82871 gammaDPGA (R)-2-aminopentanedioic acid H-D-Glu-OH KSC491O5N ACT08602 NCGC00024501-01 BDBM26431 PDSP2_000130 R-(-)-Glutamate D-2-Aminoglutaric acid SCHEMBL43222 D-Glutamic acid, >=99% (TLC) Tox21_113052 DB02517 delta-Glutaminic acid EN300-78764 (2R)-2-aminopentanedioicacid Glutamic acid # AB0010642 Lopac-gamma-2128 AK-47369 NCGC00024501-04 BR-47369 poly-D-gamma-glutamic acid CTK3J1756 RP21121 D-alpha-Aminoglutaric acid ST075000 D-Glutaminic acid WHUUTDBJXJRKMK-GSVOUGTGSA-N delta-2-Aminopentanedioate DSSTox_CID_28601 gamma-poly(D-glutamic acid) (R)-2-Aminoglutaric acid; (R)-2-Aminopentanedioic acid; D-Glu; R-(-)-1-Aminopropane-1,3-dicarboxylic acid Glutamic acid, D- [ Show all ]
Inchi Key	WHUUTDBJXJRKMK-GSVOUGTGSA-N
Inchi ID	InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
PubChem CID	23327
ChEMBL	CHEMBL76232
IUPHAR	N/A
BindingDB	26431
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	4400.0 nM	PMID9357538, PMID12213064	BindingDB,ChEMBL
EC50	13650.0 nM	PMID25958247	BindingDB

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417