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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Metabotropic glutamate receptor 7
Species	Rattus norvegicus (Rat)
Gene	Grm7
Synonym	GLUR7 glutamate receptor GPRC1G mGlu7 receptor mGlu7a receptor mGluR7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	915
Amino acid sequence	MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
UniProt	P35400
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3879
IUPHAR	295
DrugBank	N/A

Ligand

Name	D-glutamic acid
Molecular formula	C5H9NO4
IUPAC name	(2R)-2-aminopentanedioic acid
Molecular weight	147.13
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-3.7
Synonyms	AC1L2M41 NCGC00015470-01 AS-12791 PDSP1_001486 CHEBI:53375 R-(-)-1-Aminopropane-1,3-dicarboxylic acid D-2-Aminoglutarate SC-49449 D-Glutamic acid, >=99% Tocris-0217 D0YB9P delta-Glutaminate EINECS 230-000-8 (2R)-2-aminopentanedioic acid GLUTAMIC ACID 138-16-9 KS-00000A9T Lopac-G-2128 AJ-24146 NCGC00024501-03 BPBio1_001130 poly(D-glutamicacid) CS-6255 R-(?)-1-Aminopropane-1,3-dicarboxylic acid D-2-Aminopentanedioic acid SR-01000597732-1 D-Glutamicacid UNII-Q479989WEA delta-2-Aminoglutaric acid DGL G0057 (R)-2-Aminoglutaric acid Glutamic acid D-form 893G261 MFCD00063112 AM20100640 PDGA CAS-6893-26-1 Q-100774 D(-)-Glutamic acid, 99+% SBB006707 D-glutamate TC-066721 D-[14C]Glu ZINC895124 delta-Glutamate DSSTox_RID_82871 gammaDPGA (R)-2-aminopentanedioic acid H-D-Glu-OH AC-15064 ACT08602 NCGC00024501-01 BDBM26431 PDSP2_000130 R-(-)-Glutamate D-2-Aminoglutaric acid SCHEMBL43222 D-Glutamic acid, >=99% (TLC) Tox21_113052 DB02517 delta-Glutaminic acid EN300-78764 (2R)-2-aminopentanedioicacid Glutamic acid # KSC491O5N Lopac-gamma-2128 AK-47369 NCGC00024501-04 BR-47369 poly-D-gamma-glutamic acid CTK3J1756 RP21121 D-alpha-Aminoglutaric acid ST075000 D-Glutaminic acid WHUUTDBJXJRKMK-GSVOUGTGSA-N delta-2-Aminopentanedioate DSSTox_CID_28601 gamma-poly(D-glutamic acid) (R)-2-Aminoglutaric acid; (R)-2-Aminopentanedioic acid; D-Glu; R-(-)-1-Aminopropane-1,3-dicarboxylic acid Glutamic acid, D- AB0010642 AC-24113 MolPort-002-499-418 ANW-35567 PDSP1_000131 CHEBI:15966 Q479989WEA D-(-)-Glutamic acid SC-09473 TL806175 D0O1AK delta-Glutamic acid E620 glutamate (r)-glutamic acid HY-100805 AI3-09072 NCGC00024501-02 Biomol-NT_000169 PDSP2_001470 CHEMBL76232 R-(-)-Glutamic acid D-2-Aminopentanedioate SR-01000597732 D-Glutamic acid, Vetec(TM) reagent grade, >=99% UNII-61LJO5I15S component WHUUTDBJXJRKMK-GSVOUGTGSA-N delta-2-Aminoglutarate delta-Glutaminsaeure FT-0624571 (r)-1-aminopropane-1,3-dicarboxylic acid glutamic acid d- 6893-26-1 L(+)-Glutamic acid M02964 AKOS015854118 NSC 77686 C00217 PubChem10977 D(-)-Glutamic acid RTC-066721 D-Glu ST2406765 D-Glutaminsaeure Z-0144 delta-2-Aminopentanedioic acid DSSTox_GSID_48675 gamma-poly(D-glutamic acid) macromolecule (R)-2-aminopentanedioate GTPL4708 AB1001986 [ Show all ]
Inchi Key	WHUUTDBJXJRKMK-GSVOUGTGSA-N
Inchi ID	InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
PubChem CID	23327
ChEMBL	CHEMBL76232
IUPHAR	N/A
BindingDB	26431
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<100000.0 nM	PMID25958247	BindingDB
EC50	5400000.0 nM	PMID9357538	BindingDB,ChEMBL

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