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GLASS

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GPCR

Name	Metabotropic glutamate receptor 1
Species	Rattus norvegicus (Rat)
Gene	Grm1
Synonym	mGluR1 SCAR13 mGlu1 receptor metabotropic glutamate receptor 1 wobl GPRC1A glutamate receptor, metabotropic 1 glutamate receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	1199
Amino acid sequence	MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPIPVRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSAHFSPPSSPSMVVHRRGPPVATTPPLPPHLTAEETPLFLADSVIPKGLPPPLPQQQPQQPPPQQPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNSLRSLYPPPPPPQHLQMLPLHLSTFQEESISPPGEDIDDDSERFKLLQEFVYEREGNTEEDELEEEEDLPTASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL
UniProt	P23385
Protein Data Bank	1iss, 1isr, 1ewk
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 1iss.
BioLiP	BL0023849, BL0023850,BL0023851, BL0011887,BL0011889, BL0011888,BL0011890
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4477
IUPHAR	289
DrugBank	N/A

Ligand

Name	D-glutamic acid
Molecular formula	C5H9NO4
IUPAC name	(2R)-2-aminopentanedioic acid
Molecular weight	147.13
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-3.7
Synonyms	SC-09473 TL806175 D0O1AK delta-Glutamic acid E620 glutamate (r)-glutamic acid HY-100805 AC-24113 MolPort-002-499-418 ANW-35567 PDSP1_000131 CHEBI:15966 Q479989WEA D-(-)-Glutamic acid D-2-Aminopentanedioate SR-01000597732 D-Glutamic acid, Vetec(TM) reagent grade, >=99% UNII-61LJO5I15S component WHUUTDBJXJRKMK-GSVOUGTGSA-N delta-2-Aminoglutarate delta-Glutaminsaeure FT-0624571 (r)-1-aminopropane-1,3-dicarboxylic acid glutamic acid d- 6893-26-1 L(+)-Glutamic acid AI3-09072 NCGC00024501-02 Biomol-NT_000169 PDSP2_001470 CHEMBL76232 R-(-)-Glutamic acid RTC-066721 D-Glu ST2406765 D-Glutaminsaeure Z-0144 delta-2-Aminopentanedioic acid DSSTox_GSID_48675 gamma-poly(D-glutamic acid) macromolecule (R)-2-aminopentanedioate GTPL4708 AB1001986 M02964 AKOS015854118 NSC 77686 C00217 PubChem10977 D(-)-Glutamic acid D-2-Aminoglutarate SC-49449 D-Glutamic acid, >=99% Tocris-0217 D0YB9P delta-Glutaminate EINECS 230-000-8 (2R)-2-aminopentanedioic acid GLUTAMIC ACID 138-16-9 KS-00000A9T AC1L2M41 NCGC00015470-01 AS-12791 PDSP1_001486 CHEBI:53375 R-(-)-1-Aminopropane-1,3-dicarboxylic acid D-2-Aminopentanedioic acid SR-01000597732-1 D-Glutamicacid UNII-Q479989WEA delta-2-Aminoglutaric acid DGL G0057 (R)-2-Aminoglutaric acid Glutamic acid D-form 893G261 Lopac-G-2128 AJ-24146 NCGC00024501-03 BPBio1_001130 poly(D-glutamicacid) CS-6255 R-(?)-1-Aminopropane-1,3-dicarboxylic acid SBB006707 D-glutamate TC-066721 D-[14C]Glu ZINC895124 delta-Glutamate DSSTox_RID_82871 gammaDPGA (R)-2-aminopentanedioic acid H-D-Glu-OH AC-15064 MFCD00063112 AM20100640 PDGA CAS-6893-26-1 Q-100774 D(-)-Glutamic acid, 99+% D-2-Aminoglutaric acid SCHEMBL43222 D-Glutamic acid, >=99% (TLC) Tox21_113052 DB02517 delta-Glutaminic acid EN300-78764 (2R)-2-aminopentanedioicacid Glutamic acid # KSC491O5N ACT08602 NCGC00024501-01 BDBM26431 PDSP2_000130 R-(-)-Glutamate RP21121 D-alpha-Aminoglutaric acid ST075000 D-Glutaminic acid WHUUTDBJXJRKMK-GSVOUGTGSA-N delta-2-Aminopentanedioate DSSTox_CID_28601 gamma-poly(D-glutamic acid) (R)-2-Aminoglutaric acid; (R)-2-Aminopentanedioic acid; D-Glu; R-(-)-1-Aminopropane-1,3-dicarboxylic acid Glutamic acid, D- AB0010642 Lopac-gamma-2128 AK-47369 NCGC00024501-04 BR-47369 poly-D-gamma-glutamic acid CTK3J1756 [ Show all ]
Inchi Key	WHUUTDBJXJRKMK-GSVOUGTGSA-N
Inchi ID	InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
PubChem CID	23327
ChEMBL	CHEMBL76232
IUPHAR	N/A
BindingDB	26431
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	10000.0 nM	PMID9357538, PMID12213064	BindingDB,ChEMBL
EC50	23160.0 nM	PMID25958247	BindingDB
Ki	340.0 nM	PMID12109902	BindingDB

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