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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Rattus norvegicus (Rat)
Gene	Chrm2
Synonym	cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor M2 receptor cholinergic receptor, muscarinic 2, cardiac [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P10980
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL309
IUPHAR	14
DrugBank	N/A

Ligand

Name	Oxotremorine M
Molecular formula	C11H19N2O+
IUPAC name	trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium
Molecular weight	195.286
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	-0.1
Synonyms	oxotremorine-M ZINC1547932 2-Butyn-1-aminium, N,N,N-trimethyl-4-(2-oxo-1-pyrrolidinyl)- C11H19N2O DivK1c_000379 KBioSS_002548 NCGC00015758-02 SCHEMBL4542695 63939-65-1 CHEMBL23957 IDI1_000379 Lopac0_000954 NCGC00024979-01 Trimethyl-[4-(2-oxo-pyrrolidin-1-yl)-but-2-ynyl]-ammonium; iodide AC1Q6FK0 D02WTM KBio2_005107 N,N,N-trimethyl-4-(2-oxopyrrolidin-1-yl)but-2-yn-1-aminium OXO-M PDSP1_000571 [3H]oxotremorine-M CCG-205035 GTPL303 L000458 NCGC00015758-03 Spectrum_001982 KBio1_000379 LS-176344 NCGC00024979-02 trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium BDBM50005677 D0G4CG KBio2_007675 NCGC00015758-01 PDSP2_000569 CHEBI:38322 GTPL8595 Lopac-O-100 NCGC00015758-04 Tocris-1067 AC1L1ILG CHEMBL44674 KBio2_002539 N,N,N-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-aminium NINDS_000379 [ Show all ]
Inchi Key	CANZROMYQDHYHR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1
PubChem CID	4629
ChEMBL	CHEMBL44674
IUPHAR	303, 8595
BindingDB	50005677
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.78 nM	PMID8246221	BindingDB
Ki	60.0 nM	PMID8246221	BindingDB
Ki	756.0 nM	PMID8968358	BindingDB
Ki	910.0 nM	PMID8246221	BindingDB
Ki	1500.0 nM	PMID8246221	BindingDB

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