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Name | P2Y purinoceptor 14 |
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Species | Mus musculus (Mouse) |
Gene | P2ry14 |
Synonym | G protein-coupled receptor 105 G-protein coupled receptor 105 GPR105 G protein coupled receptor for UDP-glucose P2Y purinoceptor 14 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 338 |
Amino acid sequence | MNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFITGLLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRYYKIVKPLLTSIVQSVNYSKLLSVLVWMLMLLLAVPNIILTNQGVKEVTKIQCMELKNELGRKWHKASNYIFVSIFWVVFLLLIVFYTAITRKIFKSHLKSRKNSTSVKRKSSRNIFSIVLVFVVCFVPYHIARIPYTKSQTEGHYSCRTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLHMSLKVQNDLEVSKTKRENAIHESTDTL |
UniProt | Q9ESG6 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1770046 |
IUPHAR | 330 |
DrugBank | N/A |
Name | CHEMBL1771240 |
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Molecular formula | C28H25N5O |
IUPAC name | N-(3-ethenylphenyl)-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide |
Molecular weight | 447.542 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 4.3 |
Synonyms | SCHEMBL13246210 2-(pyridin-3-yl)-4-o-tolyl-N-(3-vinylphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide BDBM50343105 |
Inchi Key | WGEVQWOFROFDCU-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H25N5O/c1-3-20-9-6-11-22(16-20)30-28(34)33-15-13-25-24(18-33)26(23-12-5-4-8-19(23)2)32-27(31-25)21-10-7-14-29-17-21/h3-12,14,16-17H,1,13,15,18H2,2H3,(H,30,34) |
PubChem CID | 54584497 |
ChEMBL | CHEMBL1771240 |
IUPHAR | N/A |
BindingDB | 50343105 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 1200.0 nM | PMID21507642 | BindingDB,ChEMBL |
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