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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	G-protein coupled receptor 183
Species	Mus musculus (Mouse)
Gene	Gpr183
Synonym	GPR183 G protein-coupled receptor 183 Epstein-Barr virus-induced gene 2 Epstein-Barr virus-induced G-protein coupled receptor 2 homolog {ECO:0000250\|UniProtKB:P32249} EBV-induced G-protein coupled receptor 2 homolog {ECO:0000250\|UniProtKB:P32249} EBV-induced G protein-coupled receptor 2 EBI2 {ECO:0000250\|UniProtKB:P32249} EBI2 lymphocyte-specific G protein-coupled receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MANNFTTPLATSHGNNCDLYAHHSTARVLMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSMNLVISDILFTTALPTRIAYYALGFDWRIGDALCRVTALVFYINTYAGVNFMTCLSIDRFFAVVHPLRYNKIKRIEYAKGVCLSVWILVFAQTLPLLLTPMSKEEGDKTTCMEYPNFEGTASLPWILLGACLLGYVLPITVILLCYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFILCFTPYHVAIIQHMIKMLCSPGALECGARHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMKMLKRQVSVSISSAVRSAPEENSREMTESQMMIHSKASNGR
UniProt	Q3U6B2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259471
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3262879
Molecular formula	C21H21BrN2O2
IUPAC name	(E)-3-(4-bromophenyl)-1-[4-(2-phenylacetyl)piperazin-1-yl]prop-2-en-1-one
Molecular weight	413.315
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.4
Synonyms	BDBM50011721 (E)-3-(4-bromophenyl)-1-[4-(2-phenylacetyl)piperazin-1-yl]prop-2-en-1-one
Inchi Key	WEMKDXBKPLKJDT-DHZHZOJOSA-N
Inchi ID	InChI=1S/C21H21BrN2O2/c22-19-9-6-17(7-10-19)8-11-20(25)23-12-14-24(15-13-23)21(26)16-18-4-2-1-3-5-18/h1-11H,12-16H2/b11-8+
PubChem CID	86579900
ChEMBL	CHEMBL3262879
IUPHAR	N/A
BindingDB	50011721
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	28.84 nM	PMID24678947	ChEMBL
IC50	29.0 nM	PMID24678947	BindingDB,ChEMBL

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