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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	RACLOPRIDE
Molecular formula	C15H20Cl2N2O3
IUPAC name	3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
Molecular weight	347.236
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.9
Synonyms	HMS3268I08 NC00002 R0094 (-)-raclopride S-(-)-raclopride 3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide (raclopride) TC-143216 84225-95-6 API0006951 BRD-K04111260-001-01-9 CTK8B6813 DSSTox_RID_81059 GTPL3299 KS-000017HH NCGC00025303-03 (S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide SCHEMBL116054 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide Tox21_110961_1 AB00639928-12 BDBM50005118 CCG-100752 D08CIE HMS2089C20 MLS001423957 NCGC00025303-06 (-)-(S)-3,5-Dichlor-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-hydroxy-o-anisamid Raclopridum 104953-11-9 SR-01000597538-1 430K3SOZ7G [3H]-raclopride AKOS015966951 BN0436 CHEMBL8809 DSSTox_CID_25687 DTXSID9045687 HMS3713O20 NCGC00025303-01 Racloprida (?)- Raclopride S-raclopride 3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide(Raclopride) Tocris-1810 AX8150642 BRD-K04111260-001-05-0 D03GLO GTPL94 Meglitinides NCGC00025303-04 Raclopride [INN:BAN] (S)-3,5-Dichloro-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-hydroxy-6-methoxybenzamide SMR000449275 3,5-dichloro-N-{[(2s)-1-ethylpyrrolidin-2-yl]methyl}-2-hydroxy-6-methoxybenzamide UNII-430K3SOZ7G AC1MHWAC Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-hydroxy-6-methoxy-, (-)- CHEBI:92070 HMS2232D05 MolPort-003-983-671 PDSP1_000924 (-)-(S)-3,5-Dichloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-hydroxy-o-anisamide Raclopridum [Latin] 3,5-Dichloro-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide SR-01000597538-3 [3H]raclopride ANW-54471 BPBio1_001215 CPD000449275 DSSTox_GSID_45687 FLA 870 KB-211375 NCGC00025303-02 Racloprida [Spanish] (S)-3,5-dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide SAM001247072 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide Tox21_110961 A-40664 B6864 CAS-84225-95-6 D07MEH HMS2051C03 MLS000758220 NCGC00025303-05 Raclopride;3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide (S)3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide SR-01000597538 ZINC25757754 AJ-32768 Biomol-NT_000027 DB12518 [ Show all ]
Inchi Key	WAOQONBSWFLFPE-VIFPVBQESA-N
Inchi ID	InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1
PubChem CID	3033769
ChEMBL	CHEMBL8809
IUPHAR	94, 3299
BindingDB	50005118
DrugBank	DB12518
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Bmax	24.6 pM (mg of protein)-1	PMID2966245	ChEMBL
IC50	1.3 nM	PMID3172140	BindingDB,ChEMBL
IC50	3.4 nM	PMID12361392	BindingDB,ChEMBL
IC50	7.2 nM	PMID14592497	BindingDB,ChEMBL
IC50	14.0 nM	PMID3172140	BindingDB,ChEMBL
IC50	32.0 nM	PMID1535660, PMID1973734, PMID1969484, PMID1672158	BindingDB,ChEMBL
Kd	1.1 nM	PMID2966245	BindingDB,ChEMBL
Kd	1.2 nM	PMID4015674	IUPHAR
Kd	7.1 nM	PMID2966245	BindingDB,ChEMBL
Ki	0.501187 - 19.9526 nM	PMID1975644, PMID10617689	IUPHAR
Ki	1.0 nM	PMID11171942	BindingDB
Ki	1.1 nM	PMID8093734, PMID2136916	BindingDB,ChEMBL
Ki	1.3 nM	PMID1969484, PMID1672158	BindingDB,ChEMBL
Ki	1.8 nM	PMID1975644, PMID1840645, PMID2391685	BindingDB,ChEMBL
Ki	1.99 nM	PMID7908055	BindingDB
Ki	2.6 nM	PMID26164842	BindingDB,ChEMBL
Ki	8.29 nM	PMID1827843	ChEMBL
Ki	8.3 nM	PMID1827843	BindingDB
Ki	9.5 nM	PMID1535660	BindingDB,ChEMBL
Ki	26.0 nM	PMID2869639	BindingDB
Ki	32.0 nM	PMID2869639	BindingDB
Ki	32.8 nM	PMID1827843	BindingDB,ChEMBL
Ki	134.0 nM	PMID2869639	BindingDB
Ki	880.0 nM	PMID9021894	BindingDB

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