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Name | Beta-3 adrenergic receptor |
---|---|
Species | Canis lupus familiaris (Dog) |
Gene | ADRB3 |
Synonym | Beta-3 adrenoceptor Beta-3 adrenoreceptor |
Disease | N/A for non-human GPCRs |
Length | 405 |
Amino acid sequence | MAPWPHGNGSVASWPAAPTPTPDAANTSGLPGAPWAVALAGALLALEVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGRWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRVGADAEAQRCHSNPHCCAFASNIPYALLSSSVSFYLPLLVMLFVYARVFLVATRQLRLLRRELGRFPPAESPPAASRSRSPGPARRCASPAAVPSDRLRPARLLPLREHRALRTLGLIVGTFTLCWLPFFVANVMRALGGPSLVPSPALLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCRREEHRAAASPPGDPSAAPAALTSPAESSRCQALDGASWGIS |
UniProt | O02662 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4400 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL3128188 |
---|---|
Molecular formula | C24H27N5O2 |
IUPAC name | (6S)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-6-carboxamide |
Molecular weight | 417.513 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 3 |
XlogP | 1.9 |
Synonyms | BDBM50448789 SCHEMBL12877400 (6S)-N-[4-[[(2S)-5alpha-[(R)-Hydroxy(3-pyridinyl)methyl]pyrrolidine-2alpha-yl]methyl]phenyl]-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-6-carboxamide |
Inchi Key | VXXIYUBYYXZZOE-FCJDFRRUSA-N |
Inchi ID | InChI=1S/C24H27N5O2/c30-23(17-2-1-12-25-15-17)21-9-7-19(27-21)14-16-3-5-18(6-4-16)28-24(31)22-10-8-20-11-13-26-29(20)22/h1-6,11-13,15,19,21-23,27,30H,7-10,14H2,(H,28,31)/t19-,21+,22-,23+/m0/s1 |
PubChem CID | 70792359 |
ChEMBL | CHEMBL3128188 |
IUPHAR | N/A |
BindingDB | 50448789 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 86.0 % | PMID24437735 | ChEMBL |
EC50 | 22.0 nM | PMID24437735 | BindingDB,ChEMBL |
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