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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Bombesin receptor subtype-3
Species	Homo sapiens (Human)
Gene	BRS3
Synonym	bombesin receptor subtype-3 BRS-3 bombesin like receptor 3 BB3 receptor bb3
Disease	Breast cancer Cancer
Length	399
Amino acid sequence	MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
UniProt	P32247
Protein Data Bank	N/A
GPCR-HGmod model	P32247
3D structure model	This predicted structure model is from GPCR-EXP P32247.
BioLiP	N/A
Therapeutic Target Database	T68887
ChEMBL	CHEMBL4080
IUPHAR	40
DrugBank	N/A

Ligand

Name	CHEMBL1088553
Molecular formula	C23H31N5
IUPAC name	7-[4-[2-[5-(2,2-dimethylbutyl)-1H-imidazol-2-yl]ethyl]phenyl]-1,4,5,6-tetrahydropyrazolo[3,4-b]pyridine
Molecular weight	377.536
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.6
Synonyms	7-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridine BDBM50316908 SCHEMBL3516170
Inchi Key	BZQGYQLMMTVEDK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H31N5/c1-4-23(2,3)14-19-16-24-21(26-19)12-9-17-7-10-20(11-8-17)28-13-5-6-18-15-25-27-22(18)28/h7-8,10-11,15-16H,4-6,9,12-14H2,1-3H3,(H,24,26)(H,25,27)
PubChem CID	25026058
ChEMBL	CHEMBL1088553
IUPHAR	N/A
BindingDB	50316908
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Activity	101.0 %	PMID20347296	ChEMBL
EC50	42.0 nM	PMID20347296	BindingDB,ChEMBL
IC50	18.0 nM	PMID20347296	BindingDB,ChEMBL

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