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GLASS

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GPCR

Name	Metabotropic glutamate receptor 7
Species	Homo sapiens (Human)
Gene	GRM7
Synonym	GLUR7 glutamate receptor GPRC1G mGlu7 receptor mGlu7a receptor mGluR7 [ Show all ]
Disease	N/A
Length	915
Amino acid sequence	MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
UniProt	Q14831
Protein Data Bank	5c5c, 3mq4
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 5c5c.
BioLiP	BL0319784,BL0319785,BL0319786,, BL0181059, BL0181060, BL0319782,BL0319783
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3777
IUPHAR	295
DrugBank	BE0000834

Ligand

Name	dl-O-Phosphoserine
Molecular formula	C3H8NO6P
IUPAC name	2-amino-3-phosphonooxypropanoic acid
Molecular weight	185.072
Hydrogen bond acceptor	7
Hydrogen bond donor	4
XlogP	-5.1
Synonyms	99377-EP2272973A1 BZQFBWGGLXLEPQ-UHFFFAOYSA-N EINECS 241-834-7 NSC 90791 P-serine serine-3-p TR-008204 2-amino-3-phosphonooxy-propanoic acid 3-P-serine 99377-EP2301940A1 CS-0003781 DL-Serine dihydrogen phosphate FT-0625495 O-Phospho-DL-serine SBB000251 seryl phosphate (2S)-2-amino-3-(oxyphosphinyloxyphosphinyl)propanoic acid 6642AH AKOS015998288 DL-2-Amino-3-hydroxypropanoic acid 3-phosphate DL-Serine, dihydrogen phosphate (ester) L000353 o-phosphoserin Serine, dihydrogen phosphate (ester) (9CI) ST023488 2-amino-3-(oxyphosphinyloxyphosphinyl)propanoic acid 2-amino-3-phosphonooxypropanoic acid 99377-EP2277872A1 C3H8NO6P DL-O-Serine phosphate Energoserina NSC-90791 phosphorylserine serine-3-phosphate TR-016265 3-phospho-1-serine AC1L18HR CTK8B4010 DL-Serine monophosphorate H-DL-Ser(H2PO3)-OH O-Phospho-DL-serine, >=98.0% (NT) SCHEMBL6847 SR-01000075466 99377-EP2272972A1 ANW-43666 DL-O-Phosphorylserine DL-SOP MCULE-1695816394 P-ser Serine, dihydrogen phosphate (ester), DL- (8CI) ST51006697 2-amino-3-(phosphonooxy)propanoic acid 3-(Phosphonooxy)-2-aminopropanoic acid 99377-EP2295550A2 CHEBI:37712 DL-Phosphoserine FCH1116586 NSC90791 phosphoserine Serophen ZX-AN023561 3-phospho-serine ACMC-20ak07 D -2-Amino-3-hydroxypropanoic acid 3-phosphate DL-Serine monophosphoric acid HY-15130 o-Phosphonoserine serine phosphate SR-01000075466-1 17885-08-4 [ Show all ]
Inchi Key	BZQFBWGGLXLEPQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)
PubChem CID	106
ChEMBL	N/A
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID9131252	PDSP

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