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GLASS

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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Rattus norvegicus (Rat)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P08482
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL276
IUPHAR	13
DrugBank	N/A

Ligand

Name	tranylcypromine
Molecular formula	C9H11N
IUPAC name	(1R,2S)-2-phenylcyclopropan-1-amine
Molecular weight	133.194
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	1.5
Synonyms	BDBM50240772 Cyclopropanamine, 2-phenyl-, trans- DTXSID2023694 Jatrosom Parnate (+/-)-trans-2-phenylcyclopropylamine rel-Tranylcypromine (1R,2S)-2-phenylcyclopropan-1-amine trans-2-phenyl-cyclopropylamine (tranylcypromine)2-Phenyl-cyclopropylamine ZINC1482197 95-62-5 BRN 3195803 CS-0008259 Cyclopropylamine, 2-phenyl-, (1S-trans)- FCH3609496 LS-58822 PDSP2_001080 (.+/-.)-trans-2-Phenylcyclopropylamine SKF-trans-385 (1r,2s)-rel-2-phenylcyclopropanamine trans-2-Phenylcyclopropylamine 3-12-00-02797 (Beilstein Handbook Reference) AC1Q1HO4 AK173621 CHEBI:131510 Cyclopropanamine, 2-phenyl-, (1R-trans)- Cyclopropylamine, 2-phenyl-, trans-(.+/-.)- GJZ NE64561 (+)-(R)-Tranylcypromine Prestwick2_000173 (1R,2S)-(-)-2-phenylcyclopropylamine trans-(-)-2-Phenylcyclopropanamine (1R-trans)-2-phenyl-cyclopropanamine BRD-K47029922-003-03-4 CHEMBL1179 Cyclopropanamine, 2-phenyl-, trans-(+-)- EINECS 205-841-9 l-Tranylcypromine Parnate (Salt/Mix) (-)-Tranylcypromine S-Tranylcypromine (1R,2S)-2-phenylcyclopropanamine trans-2-phenylcyclopropan-1-amine 155-09-9 [(trans)-2-phenylcyclopropyl]amine AC-15970 CBChromo1_000132 CTK3G8797 Cyclopropylamine, 2-phenyl-, trans-(+-)- FCH4526577 LS-58823 Prestwick0_000173 (.+/-.)-Tranylcypromine SPBio_001986 (1R,2S)-trans-tranylcypromine trans-amine 3721-26-4 AELCINSCMGFISI-DTWKUNHWSA-N AKOS006282586 CHEBI:94631 Cyclopropanamine, 2-phenyl-, (1R-trans)- (9CI) d-Tranylcypromine HSDB 3404 NSC 80664 (+)-Tranylcypromine rac-trans-Tranylcypromine (1R,2S)-2-phenyl-cyclopropylamine trans-2-phenyl cyclopropylamine (Trans)-2-phenylcyclopropanamine UNII-3E3V44J4Z9 component AELCINSCMGFISI-DTWKUNHWSA-N 8372AH BRN 2802413 cid_2723716 Cyclopropanamine, 2-phenyl-, trans-(.+/-.)- EN300-197006 Lopac-P-8511 PDSP2_001079 (.+/-.)-trans-2-Phenylcyclopropamine SCHEMBL34339 (1R,2S)-rel-2-phenylcyclopropan-1-amine trans-2-phenylcyclopropanamine 2-Phenyl-1-aminocyclopropane, trans- [trans-2-phenylcyclopropyl]amine AC1L2E8J CCRIS 3344 Cyclopropanamine, 2-phenyl-, (1R,2S)-rel- Cyclopropylamine, 2-phenyl-, trans-(-)- FCH837207 NCGC00015848-01 Prestwick1_000173 (1R)-1-Amino-2-phenylcyclopropane trans amine (1R,2S)-tranylcypromine Transamine 4694AJ AJ-26319 [ Show all ]
Inchi Key	AELCINSCMGFISI-DTWKUNHWSA-N
Inchi ID	InChI=1S/C9H11N/c10-9-6-8(9)7-4-2-1-3-5-7/h1-5,8-9H,6,10H2/t8-,9+/m0/s1
PubChem CID	19493
ChEMBL	CHEMBL1179
IUPHAR	N/A
BindingDB	50240772
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	17782.8 nM	PubChem BioAssay data set	ChEMBL

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