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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H1 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH1
Synonym	H1R HH1R
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
UniProt	P31389
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3943
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL356449
Molecular formula	C27H30N4
IUPAC name	N-[2-[2-(3,3-diphenylpropyl)-1H-imidazol-5-yl]ethyl]-2-pyridin-3-ylethanamine
Molecular weight	410.565
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	4.9
Synonyms	BDBM50409768
Inchi Key	BYIKGUJPJAOQIC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H30N4/c1-3-9-23(10-4-1)26(24-11-5-2-6-12-24)13-14-27-30-21-25(31-27)16-19-28-18-15-22-8-7-17-29-20-22/h1-12,17,20-21,26,28H,13-16,18-19H2,(H,30,31)
PubChem CID	11269875
ChEMBL	CHEMBL356449
IUPHAR	N/A
BindingDB	50409768
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Concentration	10.0 uM	PMID14640554	ChEMBL
EC50	77.62 nM	PMID14640554	ChEMBL
EC50	83.18 nM	PMID14640554	ChEMBL
Emax	64.0 %	PMID14640554	ChEMBL
Emax	73.0 %	PMID14640554	ChEMBL
Kd	3.236 nM	PMID14640554	ChEMBL
Kd	3.24 nM	PMID14640554	BindingDB
pKp	6.52 -	PMID14640554	ChEMBL
Relative potency	195.0 -	PMID14640554	ChEMBL
Relative potency	254.0 -	PMID14640554	ChEMBL

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