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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Beta-2 adrenergic receptor
Species	Cavia porcellus (Guinea pig)
Gene	Adrb2
Synonym	Beta-2 adrenoceptor Beta-2 adrenoreceptor
Disease	N/A for non-human GPCRs
Length	418
Amino acid sequence	MGHLGNGSDFLLAPNASHAPDHNVTRERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMNMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWVVSGLTSFLPIQMHWYRATHKDAINCYAEETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAKKQLQKIDRSEGRFHTQNLSQVEQDGRSGHGLRRSSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSALKAYGNDCSSNSNGKTDYTGEPNVCHQGQEKERELLCEDPPGTEDLVSCPGTVPSDSIDSQGRNYSTNDSLL
UniProt	Q8K4Z4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5414
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Dichloroisoproterenol
Molecular formula	C11H15Cl2NO
IUPAC name	1-(3,4-dichlorophenyl)-2-(propan-2-ylamino)ethanol
Molecular weight	248.147
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	3.3
Synonyms	SCHEMBL613952 1-(3,4-dichlorophenyl)-2-(propan-2-ylamino)ethanol AKOS009157165 DB12803 LS-42815 2-isopropylamino-1-(3,4-dichlorophenyl)ethanol beta-Hydroxy-N-isopropyl-3,4-dichlorophenethylamine Dichlorisoproterenol PDSP1_000154 1-(3,4-Dichloro-phenyl)-2-isopropylamino-ethanol(Di chloroisoproterenol) 3,4-Dichloro-alpha-(((1-methylethyl)amino)methyl)benzenemethanol 59-61-0 CHEMBL30816 Dichloroisoproterenol,(+/-) VKMGSWIFEHZQRS-UHFFFAOYSA- 1-(3,4-Dichlorophenyl)-2-isopropylaminoethanol BDBM50036835 Dichlorisoprenaline MCULE-5460536983 1 (3,4 dichlorophenyl) 2 isopropylaminoethanol 3,4-Dichlor-isoproterenol BRN 2807251 Dichloroisoprenaline PDSP2_000153 1-(3,4-Dichlorophenyl)-2-(isopropylamino)ethanol 3,4-Dichloro-alpha-(isopropylaminomethyl)benzyl alcohol AC1L1L6H D0XX5S InChI=1/C11H15Cl2NO/c1-7(2)14-6-11(15)8-3-4-9(12)10(13)5-8/h3-5,7,11,14-15H,6H2,1-2H3 VKMGSWIFEHZQRS-UHFFFAOYSA-N 2-isopropylamino-1-(3,4-dichlorophenyl)-ethanol BENZYL ALCOHOL, 3,4-DICHLORO-alpha-((ISOPROPYLAMINO)METHYL)- Dichlorisoprenaline [German] N-(beta-(3,4-Dichlorophenyl)-beta-hydroxyethyl)isopropylamine 1-(3,4-Dichloro-phenyl)-2-isopropylamino-ethanol 3,4-Dichlor-isoproterenol [German] [ Show all ]
Inchi Key	VKMGSWIFEHZQRS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H15Cl2NO/c1-7(2)14-6-11(15)8-3-4-9(12)10(13)5-8/h3-5,7,11,14-15H,6H2,1-2H3
PubChem CID	5806
ChEMBL	CHEMBL30816
IUPHAR	N/A
BindingDB	50036835
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	977.24 nM	PMID7910217	BindingDB,ChEMBL

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