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GPCR

NameGastrin/cholecystokinin type B receptor
SpeciesRattus norvegicus (Rat)
GeneCckbr
SynonymCHOLREC
Cholecystokinin-2 receptor
CCK2-R
CCK2 receptor
CCK-BR
[ Show all ]
DiseaseN/A for non-human GPCRs
Length452
Amino acid sequenceMELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTWSVLLLLLLFFIPGVVIAVAYGLISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCVQLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTWRAFDGPGAQRALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPQPLPDEDPPTPSIASLSRLSYTTISTLGPG
UniProtP30553
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3508
IUPHAR77
DrugBankN/A

Ligand

NameCHEMBL328055
Molecular formulaC22H29N5O7
IUPAC name(3S)-4-amino-3-[[2-[[(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]acetyl]amino]-4-oxobutanoic acid
Molecular weight475.502
Hydrogen bond acceptor7
Hydrogen bond donor6
XlogP-0.1
Synonyms3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-acetylamino}-succinamic acid
BDBM50026287
Inchi KeyBXTQBXLSHWQFHF-HOTGVXAUSA-N
Inchi IDInChI=1S/C22H29N5O7/c1-22(2,3)34-21(33)27-16(8-12-10-24-14-7-5-4-6-13(12)14)20(32)25-11-17(28)26-15(19(23)31)9-18(29)30/h4-7,10,15-16,24H,8-9,11H2,1-3H3,(H2,23,31)(H,25,32)(H,26,28)(H,27,33)(H,29,30)/t15-,16-/m0/s1
PubChem CID44326887
ChEMBLCHEMBL328055
IUPHARN/A
BindingDB50026287
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.

Experimental Data

ParameterValueReferenceDatabase source
ED5060.0 umol.kg-1PMID3973899ChEMBL

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