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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Rattus norvegicus (Rat)
Gene	Chrm2
Synonym	cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor M2 receptor cholinergic receptor, muscarinic 2, cardiac [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P10980
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL309
IUPHAR	14
DrugBank	N/A

Ligand

Name	CHEMBL304599
Molecular formula	C19H22N6O4S
IUPAC name	11-[2-(4-methylpiperazin-1-yl)acetyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-8-sulfonamide
Molecular weight	430.483
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	-1.3
Synonyms	BXLNCQMGWFYCMI-UHFFFAOYSA-N 11-[(4-Methyl-1-piperazinyl)acetyl]-6-oxo-6,11-dihydro-5H-pyrido[2,3-b][1,4]benzodiazepine-8-sulfonamide # CTK6I3131 11-[2-(4-methylpiperazin-1-yl)acetyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-8-sulfonamide AC1LBK9X 11-[(4-methylpiperazin-1-yl)acetyl]-6-oxo-6,11-dihydro-5h-pyrido[2,3-b][1,4]benzodiazepine-8-sulfonamide Pirenzepine, 8-sulfamoyl- 5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6-oxo-6H-pyrido[2,3-b][1,4]benzodiazepine-8-sulfonamide BDBM50012335 11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6-oxo-6,11-dihydro-5H-benzo[e]pyrido[3,2-b][1,4]diazepine-8-sulfonic acid amide [ Show all ]
Inchi Key	BXLNCQMGWFYCMI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H22N6O4S/c1-23-7-9-24(10-8-23)12-17(26)25-16-5-4-13(30(20,28)29)11-14(16)19(27)22-15-3-2-6-21-18(15)25/h2-6,11H,7-10,12H2,1H3,(H,22,27)(H2,20,28,29)
PubChem CID	537285
ChEMBL	CHEMBL304599
IUPHAR	N/A
BindingDB	50012335
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<30000.0 nM	PMID2066986	BindingDB,ChEMBL

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