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GLASS

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GPCR

Name	Relaxin receptor 1
Species	Homo sapiens (Human)
Gene	RXFP1
Synonym	Relaxin family peptide receptor 1 RX1 relaxin/insulin like family peptide receptor 1 relaxin receptor 1 RXFPR1 LGR7 leucine-rich repeat-containing G-protein-coupled receptor 7 Leucine-rich repeat-containing G-protein coupled receptor 7 RXFP1 [ Show all ]
Disease	Acute heart failure
Length	757
Amino acid sequence	MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADEDNCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVEMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS
UniProt	Q9HBX9
Protein Data Bank	2jm4
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 2jm4.
BioLiP	BL0101296
Therapeutic Target Database	T73696
ChEMBL	CHEMBL1293316
IUPHAR	351
DrugBank	N/A

Ligand

Name	Cyclic AMP sodium
Molecular formula	C10H11N5NaO6P
IUPAC name	sodium;(4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Molecular weight	351.191
Hydrogen bond acceptor	10
Hydrogen bond donor	2
XlogP	None
Synonyms	CHEMBL1363683 MFCD00069736 Adenosine 3',5'-cyclic monophosphate monosodium salt Adenosine-3',5'-Monophosphoric Acid c-AMP sodium salt Cyclic 3',5'-amp sodium salt SMR000875274 3',5'-Cyclic AMP sodium salt Adenosine 3',5'-cyclic monophosphate sodium salt monohydrate, >=98.0% (HPLC), powder cAMP-Na I14-52594 ST24034754 6122AH Adenosine-3',5'-cyclic monophosphate monosodium salt CTK8B3794 MLS001333135 (4aR,6R,7R,7aS)-6-(6-Amino-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxide, sodium salt Adenosine 3',5'-Cyclic Monophosphate Sodium Salt AKOS015916150 C10H11N5O6P.Na sodium 3',5'-cyclic amp anion 37839-81-9 Adenosine 3',5'-phosphoric acid sodium salt LS-15117 TR-030584 AC1Q1VCB Adenosine-3',5'-cyclic monophosphate sodium salt ANW-43203 Cyclic 3',5'-(hydrogen phosphate)adenosine monosodium salt MLS001333136 3',5'-Amp sodium salt Adenosine 3',5'-cyclic monophosphate sodium salt monohydrate Camp sodium salt HMS2231C17 sodium(4ar,6r,7r,7as)-6-(6-amino-9h-purin-9-yl)-7-hydroxytetrahydro-4h-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide 60-92-4 (Parent) Adenosine, cyclic 3',5'-(hydrogen phosphate)-, monosodium salt [ Show all ]
Inchi Key	BXJBFCKTIWRKMQ-MCDZGGTQSA-M
Inchi ID	InChI=1S/C10H12N5O6P.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1
PubChem CID	23669773
ChEMBL	CHEMBL1363683
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Potency	97.4 nM	PubChem BioAssay data set	ChEMBL
Potency	218.1 nM	PubChem BioAssay data set	ChEMBL
Potency	1258.9 nM	PubChem BioAssay data set	ChEMBL

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