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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin E2 receptor EP4 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger4
Synonym	EP2 EP4 receptor PGE receptor EP4 subtype PGE2 receptor EP4 subtype Prostanoid EP4 receptor
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
UniProt	P43114
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4086
IUPHAR	343
DrugBank	N/A

Ligand

Name	CHEMBL549663
Molecular formula	C21H27NO5S
IUPAC name	2-[2-[[(4-butylphenyl)methyl-methylsulfonylamino]methyl]phenoxy]acetic acid
Molecular weight	405.509
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.9
Synonyms	2-(2-((N-(4-butylbenzyl)methylsulfonamido)methyl)phenoxy)acetic acid BDBM50293508
Inchi Key	VBBRFPKXFMMYOB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H27NO5S/c1-3-4-7-17-10-12-18(13-11-17)14-22(28(2,25)26)15-19-8-5-6-9-20(19)27-16-21(23)24/h5-6,8-13H,3-4,7,14-16H2,1-2H3,(H,23,24)
PubChem CID	45271234
ChEMBL	CHEMBL549663
IUPHAR	N/A
BindingDB	50293508
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<3200.0 nM	PMID19250823	BindingDB,ChEMBL

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