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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2086422
Molecular formula	C13H9NO4S
IUPAC name	5,6-dihydroxy-3-thiophen-3-yl-1H-indole-2-carboxylic acid
Molecular weight	275.278
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	2.5
Synonyms	BDBM50420397 SCHEMBL14702927
Inchi Key	BXECWMMWBPCAOY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H9NO4S/c15-9-3-7-8(4-10(9)16)14-12(13(17)18)11(7)6-1-2-19-5-6/h1-5,14-16H,(H,17,18)
PubChem CID	70682869
ChEMBL	CHEMBL2086422
IUPHAR	N/A
BindingDB	50420397
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	10300.0 nM	PMID24900508	BindingDB,ChEMBL
EC50	61200.0 nM	PMID24900508	BindingDB,ChEMBL
Efficacy	18.0 %	PMID24900508	ChEMBL

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