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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Leukotriene B4 receptor 1
Species	Homo sapiens (Human)
Gene	LTB4R
Synonym	BLT1 receptor BLTR Chemoattractant receptor-like 1 G-protein coupled receptor 16 GPR16 P2Y7 P2Y purinoceptor 7 LTB4-R1 LTB4-R 1 [ Show all ]
Disease	Inflammatory disease Inflammatory bowel disease Human immunodeficiency virus infection Pancreatic cancer Psoriasis Cystic fibrosis Osteoporosis Renal cancer Rheumatoid arthritis Asthma Allergy [ Show all ]
Length	352
Amino acid sequence	MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
UniProt	Q15722
Protein Data Bank	N/A
GPCR-HGmod model	Q15722
3D structure model	This predicted structure model is from GPCR-EXP Q15722.
BioLiP	N/A
Therapeutic Target Database	T59626
ChEMBL	CHEMBL3911
IUPHAR	267
DrugBank	BE0003490

Ligand

Name	CHEMBL125447
Molecular formula	C28H29NO4
IUPAC name	2-[3-[2-[methyl(2-phenylethyl)amino]-2-oxoethyl]-5-[(E)-3-phenylprop-2-enoxy]phenyl]acetic acid
Molecular weight	443.543
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.8
Synonyms	L006539
Inchi Key	BXADFEGWDORSQT-MDWZMJQESA-N
Inchi ID	InChI=1S/C28H29NO4/c1-29(15-14-23-11-6-3-7-12-23)27(30)20-24-17-25(21-28(31)32)19-26(18-24)33-16-8-13-22-9-4-2-5-10-22/h2-13,17-19H,14-16,20-21H2,1H3,(H,31,32)/b13-8+
PubChem CID	9868049
ChEMBL	CHEMBL125447
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
I	16.0 %	PMID8809163	ChEMBL

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