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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	G-protein coupled receptor 182
Species	Homo sapiens (Human)
Gene	GPR182
Synonym	NOW L1-R GPR182 Gpcr22 Gpcr17 adrenomedullin receptor ADMR [ Show all ]
Disease	N/A
Length	404
Amino acid sequence	MSVKPSWGPGPSEGVTAVPTSDLGEIHNWTELLDLFNHTLSECHVELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGIVLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASPSWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVEGPEPMCLFMAPFETYSTWALAVALSTTILGFLLPFPLITVFNVLTACRLRQPGQPKSRRHCLLLCAYVAVFVMCWLPYHVTLLLLTLHGTHISLHCHLVHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNAVVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPS
UniProt	O15218
Protein Data Bank	N/A
GPCR-HGmod model	O15218
3D structure model	This predicted structure model is from GPCR-EXP O15218.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4356
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	NSC697167
Molecular formula	C46H46N8O4
IUPAC name	2-[[4-anilino-5-[8-[4-anilino-5-[(1-hydroxynaphthalen-2-yl)oxymethyl]-1,2,4-triazol-3-yl]octyl]-1,2,4-triazol-3-yl]methoxy]naphthalen-1-ol
Molecular weight	774.926
Hydrogen bond acceptor	10
Hydrogen bond donor	4
XlogP	10.8
Synonyms	NCI60_034636 1-naphthalenol, 2,2'-[1,8-octanediylbis[[4-(phenylamino)-4h-1,2,4-triazole-5,3-diyl]methyleneoxy]]bis- 2-[[4-anilino-5-[8-[4-anilino-5-[(1-hydroxynaphthalen-2-yl)oxymethyl]-1,2,4-triazol-3-yl]octyl]-1,2,4-triazol-3-yl]methoxy]naphthalen-1-ol CHEMBL194665 NSC-697167 2-((4-Anilino-5-(8-(4-anilino-5-(((1-hydroxy-2-naphthyl)oxy)methyl)-4H-1,2,4-triazol-3-yl)octyl)-4H-1,2,4-triazol-3-yl)methoxy)-1-naphthol AC1L97GJ CTK8D3466 2-[[4-anilino-5-[8-[4-anilino-5-[(1-hydroxy-2-naphthyl)oxymethyl]-1,2,4-triazol-3-yl]octyl]-1,2,4-triazol-3-yl]methoxy]naphthalen-1-ol [ Show all ]
Inchi Key	UVKTWWXWFPPPED-UHFFFAOYSA-N
Inchi ID	InChI=1S/C46H46N8O4/c55-45-37-23-15-13-17-33(37)27-29-39(45)57-31-43-49-47-41(53(43)51-35-19-7-5-8-20-35)25-11-3-1-2-4-12-26-42-48-50-44(54(42)52-36-21-9-6-10-22-36)32-58-40-30-28-34-18-14-16-24-38(34)46(40)56/h5-10,13-24,27-30,51-52,55-56H,1-4,11-12,25-26,31-32H2
PubChem CID	394049
ChEMBL	CHEMBL194665
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Affinity	83.0 %	PMID15943480	ChEMBL

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