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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Delta-type opioid receptor
Species	Rattus norvegicus (Rat)
Gene	Oprd1
Synonym	opioid receptor OP1 DOR-1 DOR DOPr DOP delta receptor D-OR-1 Opioid receptor A [ Show all ]
Disease	N/A for non-human GPCRs
Length	372
Amino acid sequence	MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
UniProt	P33533
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL269
IUPHAR	317
DrugBank	N/A

Ligand

Name	Leu-enkephalin
Molecular formula	C28H37N5O7
IUPAC name	(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-azaniumyl-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoate
Molecular weight	555.632
Hydrogen bond acceptor	7
Hydrogen bond donor	6
XlogP	-0.5
Synonyms	N/A
Inchi Key	URLZCHNOLZSCCA-VABKMULXSA-N
Inchi ID	InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1
PubChem CID	124081685
ChEMBL	CHEMBL8234
IUPHAR	N/A
BindingDB	50001465
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	17.7 nM	PMID6296388	ChEMBL
IC50	18.0 nM	PMID6296388	BindingDB
Ki	1.4 nM	PMID11212102	BindingDB
Ki	1.43 nM	PMID11212102	ChEMBL
Ki	1.5 nM	PMID2536436	BindingDB,ChEMBL
Ki	2.5 nM	PMID10479285, PMID1331451, PMID6296388, PMID2536436, PMID8164255, PMID8230106	BindingDB
Ki	2.53 nM	PMID2536436, PMID1331451, PMID2999401, PMID20218625, PMID10479285, PMID2537427, PMID8164255, PMID8230106	ChEMBL
Ki	6.3 nM	PMID23988352	ChEMBL
Ki	8.05 nM	PMID6296388	ChEMBL
Ki	9.43 nM	PMID10691681	ChEMBL
Ki	1280.0 nM	PMID2537427	BindingDB
Ki	1320.0 nM	PMID2999401	BindingDB
Potency	1.0 -	PMID8230106	ChEMBL
Potency ratio	1.0 -	PMID2999401	ChEMBL
Ratio	0.291 -	PMID6296388	ChEMBL
Relative potency	1.0 -	PMID10479285, PMID1331451, PMID8164255, PMID2537427	ChEMBL

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