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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Mus musculus (Mouse)
Gene	Htr5a
Synonym	MR22 Htr5 5HT5- 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 5-HT5alpha 5-HT5A receptor 5-HT5A 5-HT-5A 5-HT-5 Serotonin receptor 5A [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSSLEPNRSLDTEVLRPSRPFLSAFRVLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAVEVKNATQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
UniProt	P30966
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3597
IUPHAR	10
DrugBank	N/A

Ligand

Name	1011-17-2
Molecular formula	C10H14N2O
IUPAC name	2-piperazin-1-ylphenol
Molecular weight	178.235
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.0
Synonyms	AC1Q7AO1 BDBM50017456 F2190-0532 MFCD00190246 SBB058535 Z-4262 2-Piperazinophenol AJ-15015 CTK3J4317 I14-14090 o-(1-Piperazinyl)phenol ST094948 ZINC157416 1 - (2 - Hydroxyphenyl) - piperazine 2-(1-piperazinyl)phenol AC1L2EA8 ANW-44684 DTXSID90143733 labotest-bb lt01596124 rarechem ah ck 0117 UORNTHBBLYBAJJ-UHFFFAOYSA-N 1-(2-Hydroxyphenyl)piperazine 2-Piperazin-1-yl-phenol ACMC-209v6m FS-1232 MolPort-000-156-373 SC-78281 Z1262246142 2-(1-Piperazino)phenol 2-piperazinylphenol AB0004525 AKOS000119523 D02OZB KB-08420 Oprea1_446736 ST24027656 1-(2-hydroxy-phenyl)-piperazine 2-(piperazin-1-yl)phenol AC1Q788T BBL028366 EINECS 213-782-5 MCULE-2943735251 RTR-044932 VP70103 1-(2-Hydroxyphenyl)piperazine, 97% 2-piperazin-1-ylphenol AE-562/41428846 CHEMBL266250 FT-0629153 n-(2-hydroxyphenyl)piperazine SCHEMBL531748 Z6346 2-(1-piperazinyl) phenol 4-(2-hydroxyphenyl)-piperazine AC-23077 AN-25140 DB-018439 KS-00000FY1 Phenol, 2-(1-piperazinyl)- STL186168 1-(2-Hydroxyphenyl)-piperazine 2-(piperazine-1-yl)phenol [ Show all ]
Inchi Key	UORNTHBBLYBAJJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H14N2O/c13-10-4-2-1-3-9(10)12-7-5-11-6-8-12/h1-4,11,13H,5-8H2
PubChem CID	70530
ChEMBL	CHEMBL266250
IUPHAR	N/A
BindingDB	50017456
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	215.0 nM	PMID12825922	BindingDB,ChEMBL

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