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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Rattus norvegicus (Rat)
Gene	Htr1a
Synonym	5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 5-HT-1A Gpcr18 Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	422
Amino acid sequence	MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProt	P19327
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL273
IUPHAR	1
DrugBank	N/A

Ligand

Name	1011-17-2
Molecular formula	C10H14N2O
IUPAC name	2-piperazin-1-ylphenol
Molecular weight	178.235
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.0
Synonyms	AB0004525 AKOS000119523 D02OZB KB-08420 Oprea1_446736 ST24027656 1-(2-hydroxy-phenyl)-piperazine 2-(piperazin-1-yl)phenol AC1Q788T BBL028366 EINECS 213-782-5 MCULE-2943735251 RTR-044932 VP70103 1-(2-Hydroxyphenyl)piperazine, 97% 2-piperazin-1-ylphenol 4-(2-hydroxyphenyl)-piperazine AE-562/41428846 CHEMBL266250 FT-0629153 n-(2-hydroxyphenyl)piperazine SCHEMBL531748 Z6346 2-(1-piperazinyl) phenol AC-23077 AN-25140 DB-018439 KS-00000FY1 Phenol, 2-(1-piperazinyl)- STL186168 1-(2-Hydroxyphenyl)-piperazine 2-(piperazine-1-yl)phenol 2-Piperazinophenol AC1Q7AO1 BDBM50017456 F2190-0532 MFCD00190246 SBB058535 Z-4262 AJ-15015 CTK3J4317 I14-14090 o-(1-Piperazinyl)phenol ST094948 ZINC157416 1 - (2 - Hydroxyphenyl) - piperazine 2-(1-piperazinyl)phenol AC1L2EA8 ANW-44684 DTXSID90143733 labotest-bb lt01596124 rarechem ah ck 0117 UORNTHBBLYBAJJ-UHFFFAOYSA-N 1-(2-Hydroxyphenyl)piperazine 2-Piperazin-1-yl-phenol 2-piperazinylphenol ACMC-209v6m FS-1232 MolPort-000-156-373 SC-78281 Z1262246142 2-(1-Piperazino)phenol [ Show all ]
Inchi Key	UORNTHBBLYBAJJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H14N2O/c13-10-4-2-1-3-9(10)12-7-5-11-6-8-12/h1-4,11,13H,5-8H2
PubChem CID	70530
ChEMBL	CHEMBL266250
IUPHAR	N/A
BindingDB	50017456
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	35.3 nM	PMID2565400	BindingDB,ChEMBL

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