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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Type-2 angiotensin II receptor
Species	Rattus norvegicus (Rat)
Gene	Agtr2
Synonym	angiotensin II receptor, type 2 MRX88 Agtr2 AT2R AT2-R AT2 receptor angiotensin II receptor angiotensin receptor 2 Angiotensin II type-2 receptor angiotensin II type 2 receptor AT2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	363
Amino acid sequence	MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
UniProt	P35351
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL257
IUPHAR	35
DrugBank	N/A

Ligand

Name	CHEMBL90663
Molecular formula	C36H35N5O5
IUPAC name	propan-2-yl 2-[2-butyl-4-oxo-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]imidazo[4,5-c]pyridin-5-yl]-2-phenylacetate
Molecular weight	617.706
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	6.9
Synonyms	BDBM50285811 {2-Butyl-4-oxo-3-[2''-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-biphenyl-4-ylmethyl]-3,4-dihydro-imidazo[4,5-c]pyridin-5-yl}-phenyl-acetic acid isopropyl ester
Inchi Key	BVCSSFYDTBHIHO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C36H35N5O5/c1-4-5-15-30-37-29-20-21-40(31(35(43)45-23(2)3)26-11-7-6-8-12-26)34(42)32(29)41(30)22-24-16-18-25(19-17-24)27-13-9-10-14-28(27)33-38-36(44)46-39-33/h6-14,16-21,23,31H,4-5,15,22H2,1-3H3,(H,38,39,44)
PubChem CID	136026557
ChEMBL	CHEMBL90663
IUPHAR	N/A
BindingDB	50285811
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	140.0 nM	, Bioorg. Med. Chem. Lett., (1995) 5:22:2665	BindingDB,ChEMBL

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